Indole derivatives for the treatment of osteoporosis

Details Indole derivatives for the treatment of osteoporosis Indole derivatives for the treatment of osteoporosis

2005-06-07

2005-06-07

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S201000, C546S256000, C546S277400, C546S112000, C544S316000, C544S373000, C548S312100, C548S491000, C514S253030, C514S274000, C514S299000, C514S333000, C514S339000, C514S397000, C514S419000

Reexamination Certificate

active

06903117

ABSTRACT:
A compound of formula (I):or a salt thereof, or a solvate thereof, wherein Ra represents a group R5which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a):wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRsRtwherein Rsand Rteach independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rsand Rttogether with the nitrogen to which they are attached form a heterocyclic group; R1represents an alkyl or a substituted or unsubstituted aryl group; and R2, R3and R4each independently represent hydrogen, alkyl, aryl or substituted aryl; R6and R7each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R6and R7together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and R8represents hydrogen, hydroxy, alkynoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalky, carbalkoxyalkyl, carbamoyl or aminosulphonyl; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medicine.

REFERENCES:
patent: 5296499 (1994-03-01), Sohda et al.
patent: 5981525 (1999-11-01), Farina et al.
patent: WO 93/01280 (1993-01-01), None
patent: WO 96/21644 (1996-07-01), None
Tsuda, et al., Chemical Abstracts, vol. 123, No. 23, 1995, abstract No. 306604k, p. 96.

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