Indole derivatives as interleukin-4 gene expression inhibitors

Details Indole derivatives as interleukin-4 gene expression inhibitors Indole derivatives as interleukin-4 gene expression inhibitors

2007-01-30

2007-01-30

McKenzie, Thomas (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S335000, C546S201000

Reexamination Certificate

active

10421511

ABSTRACT:
This invention discloses and claims a new class of indole derivatives for use in treating allergy, asthma, rhinitis, dermatitis, B-cell lymphomas, tumors and diseases associated with bacterial, rhinovirus or respiratory syncytial virus (RSV) infections. It has now been found that the compounds of this invention are capable of modulating T helper (Th) cells, Th1/Th2, and thereby capable of inhibiting the transcription of interleukin-4 (IL-4) message, IL-4 release or IL-4 production.

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