Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-04-29
2008-04-29
O'Sullivan, Peter (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S313000, C514S331000, C546S162000, C546S171000, C546S277100
Reexamination Certificate
active
07365081
ABSTRACT:
The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
REFERENCES:
patent: 3573294 (1971-03-01), Long et al.
patent: 5965582 (1999-10-01), Lebaut et al.
patent: 6008231 (1999-12-01), Lebaut et al.
patent: 6232327 (2001-05-01), Nickel et al.
patent: 6344467 (2002-02-01), Lebaut et al.
patent: 6432987 (2002-08-01), Gunther et al.
patent: 6693119 (2004-02-01), Nickel et al.
patent: 6706722 (2004-03-01), Emig et al.
patent: 6987122 (2006-01-01), Menta et al.
patent: 19814838 (1999-10-01), None
patent: 490 263 (1992-06-01), None
patent: 3 632 (1965-10-01), None
patent: P0101530 (2001-11-01), None
patent: WO 97/22619 (1997-06-01), None
patent: WO 98/00946 (1998-01-01), None
patent: WO 98/00946 (1999-03-01), None
patent: WO 98/09946 (1999-09-01), None
patent: WO 99/43654 (1999-09-01), None
patent: WO 99/46267 (1999-09-01), None
patent: WO 99/51224 (1999-10-01), None
patent: WO 99/55696 (1999-11-01), None
patent: WO 99/55696 (1999-11-01), None
patent: WO 99/64044 (1999-12-01), None
patent: WO 99/64044 (1999-12-01), None
patent: WO 99/65894 (1999-12-01), None
patent: WO 00/26202 (2000-05-01), None
patent: WO 99/51224 (2000-05-01), None
patent: WO 99/51224 (2000-05-01), None
patent: WO 00/31063 (2000-06-01), None
patent: WO 00/67802 (2000-11-01), None
patent: WO 00/71535 (2000-11-01), None
patent: WO 01/12189 (2001-02-01), None
patent: WO 01/17516 (2001-03-01), None
patent: WO 01/19830 (2001-03-01), None
patent: WO 01/22954 (2001-04-01), None
patent: WO 01/47913 (2001-07-01), None
patent: WO 01/47916 (2001-07-01), None
patent: WO 01/94310 (2001-12-01), None
patent: WO 02/08225 (2002-01-01), None
Chinese search rpt, Jun. 18, 2004.
Bacher Gerald et al, D-24851, A Novel Synthetic Microtubule Inhibitor, Exerts Curative Antitumoral Activity in Vivo, Shows efficacy toward multidrug-resistant tumor cells, and Lacks Nerotoxicity,; Cancer Research, American Associaton for Cancer Research, Baltimore, MD, US, Bd. 61, Nr. 1, 2001, Seiten 392-399, XP-002173885.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Fresneda, Pilar M. et al: Microwave-assisted regioselective synthesis of 2,4-disubstituted imidazoles: imidazoles: nortopsentin D synthesized by minimal effort; retrieved from STN, Database accession No. 134:281011, XP-002193292, 2001.
Bianucci, Anna Maria et al: “Benzodiazepine Receptor Affinity and Interaction of Some n-(indol-3-ylglyoxylyl) amine Derivatives”; J. Med. Chem. (1992), 35(12), 2214-20, XP-001056519.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Polymeropoulos, E. E. et al: “a Peptiedic Binding Site Model for PDE 4 Inhibitors”; retrieved from STN, Database accession No. 134:360953; XP-002193285, 2000.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Podwinski, Bohdan: “Synthesis of Some 5-benzyloxyindole-3-glyoxylic acid amides”; retrieved from STN, Database accession No. 70:37598; XP-002193286, 1966.
Polymeropoulos E. E. et al: “A Peptidic Binding Site Model for PDE 4 Inhitibors”; Quantitative Structure-Activity Relationships, VCH Publishers, Deerfield Beach, FL, US, Bd. 18, Nr. 6, 1999, Seitem 543-547, XP-001022210.
Battaglia, Sandra et al: “Indole Amide Derivatives: Synthesis, Structure-activity Relationships and Molecular Modeling Studies of A New Seires of Histamine H1-receptor Atagonists”; Eur. J. Med. Chem. (1999), 34(2), 93-105, XP-002193281.
Jiang, B. et al: “Synthesis and Cytotoxicity Evaluation of Bis(indlyl) thiazole, Bis(indolyl) pyrazinone and Bis(indolyl)pyrazine: analogues of Cytotoxic Marine Bis(indole) alkaloid”; Bioorg. Med. Chem. (2000), 8(2), 363-371, XP-002193282.
Faul, Margaret M. et al: “A New, Efficient Method for the Synthesis of Bisindolylmaleimides”; J. Org. Chem. (1998), 63(17), 6053-6058, XP-002193283.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Sarstedt, Burkhard et al: “Reactions with Indole Derivatives. XLVIII. A Simple Synthesis of the Staurosporine Aglycon” retrieved from STN, Database accession No. 98:215863 XP-002193287, 1983.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Povalyaeva, O.S. et al: “Synthesis and Properties of N-substituted 4-amino-1, 2-dithiolanes and Related Compounds”; retrieved from STN, Database accession No. 101-72646; XP-002193288, 1984.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Afsah, El Sayed M. et al: “Synthesis and Reactions of N-indol-3-ylmethylakylamines and Related Compounds”; retrieved form STN, Database accession No. 102:6101; XP-002193289, 1989.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Jiang, Biao et al: “Total Synthesis of (.+−.)-Dragmacidin: A Cytotoxic Bis(indole)alkaloid of Marine Origin”; retrieved from STN, Database accession No. 11:280941; XP-002193290, 1994.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Martini, Claudia et al: “Specific Inhibition of Benzodiazepine Receptor Binding by Some N-(indol-3-ylglyoxylyl)amino acid Derivatives”; retrieved from STN, Database accession No. 102:125088, XP-002193291, 1985.
Evans S.M. et al: “Probing the 5-TH3 Receptor Site Using Novel Indole-3-Glyoxylic Acid Derivatives” Medicinal Chemistry Research, Birkhaeuser, Boston, US, Bd. 3, Nr. 5/6, 1993, Seiten 386-406, XP-000956190.
Database CA [Online] Chemical Abstracts Service, Columbus, Ohio, US; Da Settimo, A. et al: “Synthesis and anti-inflammatory Activity of Some N-(5-substituted indol-3-ylglyoxyl)amine Derivatives”; retrieved from STN, Database accession No. 107:32773, XP-002193284, 1987.
Russian search rpt w/ translation.
Organic Chemistry Journal, vol. 20, No. 4, 1984, pp. 849-860, compounds XVIb and XIIb, p. 859.
Heterocycles, (1983), 20(3), pp. 469-476, compounds 8 and 10, pp. 471 and 473-474.
J. Med Chem., (1992), 35, (12), pp. 2214-2220, compounds 2-6 from tables 1 and 2.
J. Chem. Soc. Perkin Trans. I 1984, pp. 1929-1932.
Chemical Abstracts, 70:37598; compound with registry Nos. 21421-40-9 and compound with registry No. 21421-41-0, 1966.
Chemical Abstracts, 134:360953; compound with registry Nos. 340719-96-2, 2000.
“Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery” H.H. Flebig et al. European Journal of Cancer 2004, 40, 802-820.
Aue Beate
Bacher Gerald
Basner Silke
Emig Peter
Günther Eckhard
AEterna Zentaris GmbH
Goodwin & Procter LLP
O'Sullivan Peter
LandOfFree
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