Indole derivatives and process for preparing the same

Details Indole derivatives and process for preparing the same Indole derivatives and process for preparing the same

1977-05-20

1979-02-13

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

546248, 546201, 546184, 546245, 26032612R, 26032614R, 26032615, 424250, 424267, 544143, 544144, 544373, A61K 3140, C07D20908, C07D20930, C07D40106

Patent

active

041396340

ABSTRACT:
Indole derivatives of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl radical, R.sub.2 and R.sub.3, which are the same or different, each represent a hydrogen atom, a methyl or ethyl radical, a benzyl radical or represent together a pentamethylene, hexamethylene, oxydiethylene or N-methylaminodiethylene chain, forming thus a cycle with the nitrogen atom, R.sub.4 represents a phenyl, 2', 4'-dimethyl-phenyl, isopropyl, cyclopropyl, 1-methyl-cyclopropyl, cyclopentyl or cyclohexyl radical, R.sub.5 represents a hydrogen atom, a branched- or straight-chain alkyl radical containing from 1 to 3 carbon atoms, a methylthio or ethylthio radical or a straight-chain acyl radical containing from 2 to 6 carbon atoms, R.sub.6 represents a hydrogen atom or a halogen atom, a methyl, methoxy, hydroxy, carboxy, nitro, amino, methylamino or dimethylamino radical, R.sub.7 represents a hydrogen atom or a halogen atom and n is 1 or 2, with the proviso that two at least of the groups R.sub.5, R.sub.6 and R.sub.7 represent a hydrogen atom and that, when n is 2, one at least of the groups R.sub.2 and R.sub.3 is not a hydrogen atom, and their pharmaceutically acceptable acid addition salts.
The derivatives of the invention are useful as antidepressant and/or antiaggressive agents.

REFERENCES:
patent: 3503990 (1970-03-01), Shoen et al.
Kaji et al., Chem. Abstracts, vol. 47, cols. 9317-9318 (1953).

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