Indole derivatives

Details Indole derivatives Indole derivatives

1993-03-24

1996-07-23

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21714

Patent

active

055391192

ABSTRACT:
This invention is directed to a indole derivative represented by the general formula (1) ##STR1## wherein R.sub.1 stands for alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to 14 carbon atoms, trans-alkenyl of 4 or 5 carbon atoms, allyl, furanyl-2-ylalkyl of 1 to 5 carbon atoms, thienyl-2-ylalkyl of 1 to 5 carbon atoms, vinyloxycarbonyl, trichloroethoxycarbonyl, benzyloxycarbonyl, alkanoyl of 1 to 5 carbon atoms, aralkylcarbonyl of 7 to 14 carbon atoms, 2-furoyl, thiophene-2-carbonyl, cycloalkylcarbonyl of 4 to 7 carbon atoms, alkenylcarbonyl of 3 to 8 carbon atoms, or anisoyl, providing that said general formula (1) embraces a (+) form, a (-) form, and a (.+-.) form, or a pharmacologically acceptable salt thereof and to an immunorepressing agent having as an active component thereof the indole derivative or the pharmacologically acceptable salt thereof.

REFERENCES:
patent: 3933827 (1976-01-01), Brossi et al.
patent: 4189583 (1980-02-01), Rapoport et al.
patent: 4310667 (1982-01-01), Le Pecq et al.
patent: 4419517 (1983-12-01), Brittelli et al.
patent: 4434290 (1984-02-01), Bisagni et al.
Morrison & Boyd p. 180 & p. 757, 3rd Ed. 1976.
"Reactions of Alcohols, Phenols, and Ethers," Norman L. Allinger et al, Organic Chemistry, Second Edition, pp. 438-440.

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