Indole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514318, 514329, 514333, 546193, 546201, 546256, 546273, A61K 31445, C07D40114, C07D40304, C07D40314

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active

054571154

ABSTRACT:
A substituted indole compound having the formula I: ##STR1## where Ar is one of a phenyl group, a phenyl group substituted with at least one substituent selected from halogen, lower alkyl, lower alkoxy, hydroxy, trifluoromethyl, and cyano, and a hetero aromatic group selected from 2-thienyl, 3-thienyl, 2-furanyl, 3-furanyl, 2-oxazolyl, 2-imidazolyl, 2-pyridyl, 3-pyridyl, and 4-pyridyl; each dotted line is an optional double bond; X and X' are independently selected from the group consisting of hydrogen, halogen, lower alkyl, lower alkoxy, hydroxy, lower alkylthio, lower alkylsulfonyl, lower alkylamino, lower dialkylamino, cyano, trifluoromethyl, and trifluoromethylthio; or X and X' are taken together to form a 5 to 7 membered carbocyclic ring; R.sup.1 is selected from the group consisting of hydrogen, lower alkyl and lower alkyl substituted with one or two hydroxy groups; with the proviso that when X is hydrogen or fluoro then R.sup.1 cannot be hydrogen; R is a substituent having the formula Ib: ##STR2## wherein n is an integer from 2-6 inclusive; W is oxygen or sulfur; V.sup.1 is selected from OR.sup.4, SR.sup.5, CHR.sup.6 R.sup.7, and NR.sup.8 R.sup.9 ;

REFERENCES:
patent: 4943590 (1990-07-01), Boegesoe et al.

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