Indole derivatives

Details Indole derivatives Indole derivatives

1973-02-16

1976-01-20

Gallagher, Richard J..

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260296R, 2603191, 26032613R, 26032616, 424274, C07D20914

Patent

active

039338533

ABSTRACT:
Indoles of the formula ##SPC1##
In which R.sub.1 is phenyl, halophenyl, nitrophenyl, aminophenyl, lower alkoxyphenyl, pyridyl, benzyl, halobenzyl, lower alkoxybenzyl or a group of the formula --C.sub.n H.sub.2n NR.sub.4 R.sub.5 in which n is 2, 3 or 4 and each of R.sub.4 and R.sub.5 is hydrogen or alkyl, R.sub.2 is hydrogen, R.sub.3 is hydroxyl or R.sub.2 and R.sub.3 taken together are oxygen or NOR.sub.6 in which R.sub.6 is hydrogen, lower alkyl, lower acyl or a group of the formula --C.sub.m H.sub.2m NR.sub.7 R.sub.8 in which m is 2, 3 or 4 and each of R.sub.7 and R.sub.8 is lower alkyl, as well as the salts thereof with acids are of low toxicity and possess a pronounced analgesic effect and/or tranquillising effect and are of use in human and veterinary medicine.

REFERENCES:
patent: 3501465 (1970-03-01), Shen et al.
julia et al., Chemical Abstracts, Vol. 66, 45920d (1967).
Julis et al. (II), Bull Soc. Chim France, 1966 No. 7, pp. 2291-2295 (1966).

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