Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-05-09
1996-10-15
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514323, 514414, 5142352, 540602, 544143, 544373, 546201, 548467, A61K 31445, A61K 31495, C07D40112, C07D40312
Patent
active
055654479
ABSTRACT:
A compound of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or an alkyl group, Z represents a ring selected from: ##STR2## in which n represents 4, 5 or 6; ##STR3## in which R.sup.3 represents hydrogen or an alkyl group and R.sup.4 represents an alkyl, methoxy benzyl or R.sup.5 NHCO group, R.sup.5 being an alkyl group; and ##STR4## in which R.sup.6 represents an alkyl group. and pharmaceutically acceptable salts thereof are useful in the treatment of migraine and other conditions. They are prepares by decarboxylation of the corresponding indolyl 2-carboxylic acid.
REFERENCES:
Gonzalez, A., "A Convenient Preparation of 8-Ethyl-4,9-Dihydro-3H-Pyrano[3,4-b]Indole-1-One, Key Intermediate of the Antiinflammatory Agent Etodolac," Synthetic Communications, 21(5), pp. 669-674 (1991).
Howell, B. A., "A Convenient Method for the Preparation of 2,4-Dinitrophenylhydrazones," Journal of Chemical Education, p. 176 (1984).
Plieninger, H., "Eine Synthese des Tryptophans," from the Research Laboratory of Knoll A. G., Ludwigshafen, vol. 83, pp. 268-271 (Jan. 23, 1950).
Humphrey, P. P. A. et al., "GR43175, a selective agonist for the 5-HT.sub.1 -like receptor in dog isolated saphenous vein," Br. J. Pharmacol., vol. 94, pp. 1123-1132, (1988).
Bruinvels, A. T., et al., "5-HT.sub.1D binding sites in various species: similar pharmacological profile in dog, monkey, calf, guinea-pig and human brain membranes", Naunyn-Schmiedeberg's Arch Pharmacol, vol. 346, pp. 243-248 (1992).
Gozlan, H. et al., "Identification of presynaptic serotonin autoreceptors using a new ligand: .sup.3 H-PAT," Nature, vol. 305, pp. 140-143 (Sep. 8, 1983).
Sundberg et al, J. Org. Chem. 53 p. 5097 (1988).
Duran Carles P.
Forner Dolors F.
Mauri Jacinto M.
Noverola Armando V.
Soto Jose P.
Bernhardt Emily
Laboratorios Almirall S.A.
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