Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-11-16
1992-06-23
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514323, 514339, 514414, 514415, 514419, 540602, 544238, 544373, 546201, 546273, 548455, 548467, 548468, 548492, A61K 3140, A61K 31445, A61K 31495, A61K 31395, C07D40300, C07D40100, C07D20942
Patent
active
051243245
ABSTRACT:
Disclosed are compounds of formula I ##STR1## wherein R.sub.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, benzyl or an indolyl carbonyl group, R.sub.2 is a saturated or unsaturated 5- or 8-membered heterocyclic group containing as a hetero atom one or more nitrogen atoms, the heterocyclic group is optionally substituted at an N or C atom by a C.sub.1 -C.sub.6 alkyl or aralkyl group, n is an integer of 1 to 5 and one or more hydrogen atoms, in an alkylene chain --(CH.sub.2).sub.n -- are optionally substituted by a C.sub.1 -C.sub.6 alkyl, phenyl and/or hydroxyl group, physiologically acceptable salts and quaternary ammonium salts thereof. The compounds are selective antagonists of 5-HT.sub.3 receptors and are useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.
REFERENCES:
patent: 4486441 (1984-12-01), Fozard et al.
patent: 4563465 (1986-01-01), Fozard et al.
patent: 4789673 (1988-12-01), Donatsch et al.
patent: 4803199 (1989-02-01), Donatsch et al.
patent: 4910193 (1990-03-01), Buchheit
patent: 4910207 (1990-03-01), Donatsch et al.
Richardson et al., CA 104-19506g (1986).
Buchheit, CA 113-165432g (1990).
The New England Journal of Medicine, vol. 305, No. 16, Oct. 15, 1981, pp. 905-909, R. J. Gralla et al.
The Lanset, vol. 1, No. 8548, Jun. 27, 1987, pp. 1461-1463, D. Cunningham et al.
Physiological Reviews, vol. 53, No. 1, Jan. 1973, pp. 159-227, A. S. Paintal.
Nature, vol. 316, Jul. 11, 1985, pp. 126-131, B. P. Richardson et al.
Chemical Abstracts, vol. 87, No. 5, 1st Aug. 1977, p. 494, abstract No. 39217x, Columbus, Ohio, US; G. L. Papayan et al.
Hagihara Koichiro
Kikuchi Haruhiko
Satoh Hiroaki
Suguro Toshio
Yanai Makoto
Nisshin Flour Milling Co. Ltd.
Shen Cecilia
LandOfFree
Indole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-932923