Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-10
2010-06-29
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S410000, C514S411000, C548S311100, C548S420000, C548S431000, C548S465000
Reexamination Certificate
active
07745473
ABSTRACT:
There is provided a novel pyrrole-imidazole polyamide compound for alkylating the specific base sequence of DNA, the polyamide compound being capable of being synthesized through fewer reaction steps than known hybrid molecules and having a combination of a high reactivity in DNA alkylation and the ability to recognize a sequence. Furthermore, there is provided an alkylating agent and a molecule serving as a drug, the alkylating agent and the molecule containing the polyamide compound.An indole derivative is represented by general formula (1):wherein R1represents a functional group for alkylating DNA; R2represents a hydrogen atom, an alkyl group, or an acyl group; and X represents a divalent group having one constitutional unit or having two or more constitutional units which may be the same or different, the constitutional unit being represented by the following formula:(wherein m is an integer of 0 to 10), wherein among the constitutional units, a terminal constitutional unit adjacent to R2may be a constitutional unit represented by the following formula:(wherein k is an integer of 0 to 10).
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Bando Toshikazu
Sugiyama Hiroshi
Chu Yong
Kyoto University
Sughrue & Mion, PLLC
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