Indole derivative and method of production thereof

Details Indole derivative and method of production thereof Indole derivative and method of production thereof

1990-05-14

1992-08-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142298, 514284, 514285, 514290, 514339, 514411, 544 89, 544 99, 544101, 546 62, 546 71, 546 94, 546272, 548150, 548427, 548432, 548486, A61K 3140, C07D20130

Patent

active

051379090

ABSTRACT:
An indole derivative represented by the general formula (I) ##STR1## wherein R is hydrogen, lower alkyl having 1 to 6 carbons, carboxymethyl, or substituted or unsubstituted aralkyl; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 may be the same with or different from each other and are hydrogen, halogen, lower alkyl having 1 to 6 carbons, lower alkoxy having 1 to 6 carbons, acyl, substituted or unsubstituted amino, nitro, hydroxy, acyloxy, substituted or unsubstituted aralkyl, substituted or unsubstituted aryloxy, or substituted or unsubstituted aralkyloxy, or a combination of R.sup.2 and R.sup.3 may be methylenedioxy;

REFERENCES:
patent: 3803319 (1974-04-01), Musajo
patent: 4059583 (1977-11-01), McComsey
patent: 4654360 (1987-03-01), Greenhouse et al.
patent: 4882329 (1989-11-01), Lerch
patent: 4994474 (1991-02-01), Gubin
Ishizuka, Jour. Chem. Soc. Perkin Trans. 1, pp. 813-826 (1990).
Lednicer et al., Jour. Hetero. Chem., vol. 8, pp. 903-910 (1971).
Ishizuka et al., in 9th Int'l Congress of Het. Chem., Hokkaido Univ., 1983, p. 397.

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