Indole compounds

Details Indole compounds Indole compounds

1999-05-11

2000-12-26

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514212, 514414, 540524, 546201, 548484, A61K 3140, A61K 31435, C07D40100, C07D20936

Patent

active

06166040&

ABSTRACT:
Pharmaceutical compounds of the formula: ##STR1## in which n is 1 to 6, m is 1 or 2 and p is 1 or 2, R.sup.1 and R.sup.2 are each hydrogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, HO--C.sub.1-4 alkyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, C.sub.1-4 alkylthio, halo, optionally substituted phenyl, optionally substituted phenyl-C.sub.1-4 alkyl, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a C.sub.3-6 cycloalkyl group, >C.dbd.O, C.dbd.NOR' where R' is hydrogen or C.sub.1-4 alkyl,
R.sup.3, R.sup.4 and R.sup.5 are each hydrogen, halo, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkyl-CO--, where m is 0, 1 or 2, R'R"N--SO.sub.2 --, --COOR', --CONR'R", --NR'R", --N(OR')COOR", --COR', --NHSO.sub.2 R', where R' and R' are each hydrogen or C.sub.1-4 alkyl,
R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-4 alkyl,
X is oxygen or sulphur,
the dotted line represents an optional double bond, and the fluorine atom is attached at the 6- or 7-position; and salts thereof.

REFERENCES:
patent: 3981881 (1976-09-01), Wade et al.
patent: 5773448 (1998-06-01), Gallagher et al.
Patent Abstracts of Japan, 016:071, 03264581, Feb. 21, 1992.

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