Indole carbamates as leukotriene antagonists

Details Indole carbamates as leukotriene antagonists Indole carbamates as leukotriene antagonists

1991-10-17

1994-08-02

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, 546174, 546172, 546176, 514314, 514405, 514415, 514419, 548360, 548470, 548493, C07D40106, C07D47104, C07D24700, C07D20912, A61K 3140, A61K311415

Patent

active

053345975

ABSTRACT:
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

REFERENCES:
Matassa, et al., J. Med. Chem., 33, 1781-1790 (1990).

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