Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 19, 530331, 546146, 548128, 548131, 548136, 548143, 5482668, A61K 3805, A61K 3806, C07K 5065, C07K 5083

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active

061002380

ABSTRACT:
The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome, septic shock and multiple organ failure. A series of studies also have indicated the involvement HNE in myocardial ischemia-reperfusion injury, emphysema. HNE-mediated processes are implicated in other conditions such as arthritis, periodontal disease, glomerulonephritis, dermatitis, psoriasis, cystic fibrosis, chronic bronchitis, atherosclerosis, Alzheimer's disease, organ transplantation, corneal ulcers, and invasion behavior of malignant tumors.

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