Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-10-22
2000-11-21
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514419, A61K 3140
Patent
active
061503959
ABSTRACT:
The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: ##STR1## which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
REFERENCES:
Bradfield et al, "Structure-Activity Relationships of Dietary Indoles . . . ", Journal of Toxicology and Environmental Health, 21:311-323, Dec. 1987.
Chemical Abstracts 122:106202, "Neoascorbigen and Its Analogs: Synthesis and Study", Jul. 1994.
Bjeldanes Leonard F.
Cover Carolyn M.
Firestone Gary L.
Krass Frederick
Osman Richard Aron
The Regents of the University of California
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