Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-05-30
1999-12-14
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514419, 424 92, 435 6, 435 772, 435 78, 435 79, 435 791, 435 21, A01N 4338, A61K 31405
Patent
active
060018682
ABSTRACT:
The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: ##STR1## which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
REFERENCES:
patent: 5895797 (1999-04-01), Arffman et al.
Chemical Abstracts vol. 103:171535 c (von Angerek et al.), 1985
Chemical Abstracts vol. 115:200908 g (Bradlow et al.), 1991.
Chemical Abstracts vol. 123:339726 l (Ikeda et al.), 1995.
Ng et al--Eur. J. Pharmacol. vol. 264(1) pp. 1-12 (Abstract), 1994.
Bjeldanes Leonard F.
Coyer Carolyn M.
Firestone Gary L.
Krass Frederick
Osman Richard Aron
The Regents of the University of California
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