Indol derivatives, the method for preparing thereof and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C548S469000, C514S254090

Reexamination Certificate

active

07902190

ABSTRACT:
Disclosed are indole derivatives, a preparation method thereof, and a composition for the prevention and treatment of metabolic diseases, containing the same as an active ingredient. The indole derivatives have inhibitory activity against DGAT (diacylglycerol acyltransferase), which causes metabolic diseases such as obesity and diabetes in the process of lipid metabolism. With the ability to effectively control lipid metabolism and energy metabolism, the composition is thus useful in the prevention and treatment of metabolic diseases, such as obesity and diabetes.

REFERENCES:
patent: 6432682 (2002-08-01), Omura et al.
patent: 6608185 (2003-08-01), Omura et al.
patent: 0460438 (2003-06-01), None
patent: 0577320 (2004-04-01), None
patent: 0507989 (2004-07-01), None
patent: WO 99/35130 (1999-07-01), None
patent: WO2004/046107 (2004-06-01), None
patent: WO 2005094816 (2005-10-01), None
patent: WO2006/004200 (2006-01-01), None
patent: WO2006/019020 (2006-02-01), None
patent: WO2006/044775 (2006-04-01), None
Chen et al. (2002) “Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1,”J. Clin. Invest., 109(8), 1049-1055.
Chen, H.C., et al. (2000) “DGAT and Triglyceride Synthesis: A New Target for Obesity Treatment?”Trends Cardiovasc. Med., 10, 188-192.
Chen et al. (2003) “Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diaclyglycerol acyltransferase,”J. Clin. Invest., 111, 1715-1722.
Chen et al. (2003) “Anaysis of energy expenditure at different ambient temperatures in mice lacking DGAT1,”Am. J. Physiol. Endocronol. Metab., 284, E213-218.
Chen et al.(2005) “Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity: Lessons From DGAT1-Deficient Mice,”Arterioscler Thromb Vasc. Biol. 25(3), 482-486.
Chen et al. (2002), “Dissociation of Obesity and Impaired Glucose Disposal in Mice Overexpressing Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 in White Adipose Tissue,”Diabetes. 51(11), 3189-3195.
Ganji et al. (2004) “Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells,”Journal of Lipid Research45:1835-1845.
Rustan et al. (1988) “Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacyglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacyglycerol acyltransferase,”Journal of Lipid Research29:1417-1426.
Smith, S.J. et al.(2000) “Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat,”Nature genetics, 25, 87-90.
Subauste et. al. (2003) “DGAT: Novel Therapeutic Target for Obesity and Type 2 Diabetes Mellitus,”Current Drug Target-Immun2, Endocrine&Metabol Disorders, 3, 263-270.
Yoganathan et al. (2004) “Cochlioquinones andEpi-Cochlioquinones Antagonists of the Human Chemokine Receptor CCR5 from Bipolaris brizae andStachybotrys chartarum,” The Journal of Antibiotics57,1:59-63.
International Search Report and Written Opinion dated Jan. 7, 2008 for PCT/KR2007/00722.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Indol derivatives, the method for preparing thereof and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indol derivatives, the method for preparing thereof and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indol derivatives, the method for preparing thereof and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2777897

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.