Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-06-24
1996-09-17
LeGuyader, John L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536241, 536 253, 536 2531, 548416, 548455, 435 6, C07H 2100, C12Q 168
Patent
active
055569595
ABSTRACT:
A chemical compound of the following formula is disclosed ##STR1## where R is one of H, trityl, 4-0-monomethoxytrityl, 4,4'-O-dimethoxytrityl, or acyl groups and R may be used as a protecting group or is an H; R.sup.1 is a phosphoramidite; R.sup.11 is one of H or lower alkyl groups; R.sup.111 is one of H or lower alkyl groups; R.sup.4 is one of H, lower alkyl, acyl, or (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.3 where p is an integer from 0 to 4 and q is an integer from 0 to 4; R.sup.5 is one of H, lower alkyl, acyl, or (CH.sub.2).sub.p COO(CH.sub.2).sub.q CH.sub.3 where p is an integer from 0 to 4 and q is an integer from 0 to 4; n is an integer from 0 to 10; m is an integer from 0 to 10; and r is 1, 2, or 3.
REFERENCES:
patent: 4981977 (1991-01-01), Southwick et al.
Kenten et al. (1992) Clin. Chem. vol. 38(6); 873-879.
Patonay et al. (1991) Analy. Chem. vol. 63(6); 321-326.
Mag et al. (1989) Nuc. Acids Res. vol. 17(15): 5973-5988.
Sekine et al. (1986) J. Am. Chem. Soc. vol. 108: 4581-4586.
Collaborative Research (1978) Semiannual Progress Report No. 2, 6 Jan. 1978-15 Jul. 1978.
Nippon Zeon (1987) JP 62070391.
Schulhof et al., Nucleic Acids Research 15 (1987), pp. 397-416.
Cyanine Dye Labeling Reagents-Carboxymethylindocyanine Succinimidyl Esters, Southwick, et al., Cytometry, 11:418-430 (1990).
Synthesis of a Carbocyanine Phosphoramidite and its use in Oligonucleotide Labeling, International Conference on Nucleic Acid Medical Applications, Anderson, et al. (Jan. 15, 1993).
Sensitive Detection of RNAs in Single Cells by Flow Cytometry, Nucleic Acids Ressearch, vol. 20, No. 1:83-88, Hong Yu, et al., Dec. 4, 1991.
Ogilvie et al. Proc. Natl. Acad. Sci. USA 85 5764-5768 (1988) Total Chemical Synthesis of a 77-nucleotide-long . . . .
Seliger et al. Chem. Ber. 111 3732-3739 (1978) Kinetik der Schutzgruppenabspauling bei derivaten des . . . .
Dahl et al. Nucleic Acids Research 15 1729-1743 (1987) Mechanistic Studies on the phosphoramidite coupling reaction . . . .
Anderson Eric D.
Brush Charles K.
Brusca John S.
LeGuyader John L.
Pharmacia P-L Biochemicals Inc.
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