Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Patent
1987-07-09
1989-11-14
Warden, Robert J.
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
283 70, 283 95, 435 7, 436516, 436518, 436530, 436543, 436548, 436809, 436828, G01N 33548, G01N 33561, G01N 33566, G01N 33577
Patent
active
048807508
ABSTRACT:
An identification method, applicable to the identification of animals or inanimate objects, is described. The method takes advantage of a hithertofore unknown set of individual-specific, or IS antibodies, that are part of the unique antibody repertoire present in animals, by reacting an effective amount of IS antibodies with a particular panel, or n-dimensional array (where n is typically one or two) consisting of an effective amount of many different antigens (typically greater than one thousand), to give antibody-antigen complexes. The profile or pattern formed by the antigen-antibody complexes, termed an antibody fingerprint, when revealed by an effective amount of an appropriate detector molecule, is uniquely representative of a particular individual. The method can similarly by used to distinguish genetically, or otherwise similar individuals, or their body parts containing IS antibodies.
Identification of inanimate objects, particularly security documents, is similarly affected by associating with the documents, an effective amount of a particular individual's IS antibodies, or conversely, a particular panel of antigens, and forming antibody-antigen complexes with a particular panel of antigens, or a particular individual's IS antibodies, respectively.
One embodiment of the instant identification method, termed the blocked fingerprint assay, has applications in the area of allergy testing, autoimmune diagnostics and therapeutics, and the detection of environmental antigens such as pathogens, chemicals, and toxins.
REFERENCES:
patent: 2445586 (1948-07-01), Simons et al.
patent: 3964992 (1976-06-01), Krotz
patent: 3988230 (1976-10-01), Krotz
patent: 4031197 (1977-06-01), Marinkovich
patent: 4136229 (1979-01-01), Godet et al.
patent: 4452901 (1984-06-01), Gordon et al.
patent: 4471056 (1984-09-01), Grumet et al.
patent: 4582788 (1986-04-01), Erlich
patent: 4582789 (1986-04-01), Sheldon, III et al.
patent: 4591570 (1986-05-01), Chang
patent: 4617261 (1986-10-01), Sheldon, III et al.
patent: 4657852 (1987-04-01), Grumet et al.
patent: 4708931 (1987-11-01), Christian
patent: 4710463 (1987-12-01), Murray
patent: 4713349 (1987-12-01), Levin
"Leaving Holmes in the Dust", Newsweek, p. 81, (Oct. 26, 1987).
Wetton et al., "Demographic Study of a Wild House Sparrow Population by DNA Fingerprinting", Nature 327:147 (14 May 1987).
Nakamura et al., "Variable Number of Tandem Repeat Markers for Human Gene Mapping", Science 235:1616 (Mar. 27, 1987).
Francoeur et al., J. Immunol., 136, 1648-1653, 1986.
Gill et al., "Forensic Application of DNA Fingerprints", Nature 318:577 (Dec. 12, 1985).
Jeffreys et al., "Positive Identification of an Immigration Test-Case Using Human DNA Fingerprints", Nature 317:813 (Oct. 31, 1985).
Jeffreys et al., "Individual-Specific Fingerprints of Human DNA", Nature 316:76 (Jul. 4, 1985).
Jeffreys et al., "Hypervariable `Minisatellite` Regions in Human DNA", Nature 314:67 (7 Mar. 1985).
Wyman et al., "A Highly Polymorphic Locus in Human DNA", Proc. Natl. Acad. Sci. USA 77:6754 (Nov. 1980).
Miragen, Inc.
Saunders David A.
Warden Robert J.
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