Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-10-05
1996-03-05
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 724, 435 29, C12Q 102
Patent
active
054967031
ABSTRACT:
This invention relates to the determination of in vivo exposure to dioxinlike compounds and the in vitro quantitation of dioxinlike compounds based on protein tyrosine phosphorylation as mediated by the Ah receptor. The extent of protein tyrosine phosphorylation is determined by monoclonal antibodies to protein tyrosine phosphate. The amount and nature of protein tyrosylphosphate is quantitatively related to the in vivo or in vitro concentration of dioxin to which animals or cells were exposed. This method permits detection of dioxinlike compounds at concentrations in the parts per trillion and parts per billion range.
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Babish John G.
El-Tom Sakina
Ma Xinfang
Wheelock Goeffrey
Cornell Research Foundation Inc.
Green Lora M.
Scheiner Toni R.
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