Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Reexamination Certificate
2007-04-10
2007-04-10
Ceperley, Mary E. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
C436S529000, C530S405000, C530S406000, C530S409000, C530S410000, C530S411000, C544S360000, C544S386000
Reexamination Certificate
active
10988477
ABSTRACT:
Derivatives and conjugates of indinavir for generation of antibodies and labeled conjugates for use for detection of indinavir in biological samples. The derivatives are synthesized out of the indane ring hydroxyl group or the pyridine ring nitrogen of indinavir. Also disclosed is synthesis of a major metabolite of indinavir (M6) in a single step from indinavir using palladium catalyst and hydrogen gas. Indinavir M6 has been extended to synthesize various analogs of indinavir with suitable functional groups. These derivatives are useful in the development of indinavir immunogens, antibodies, and labeled conjugates in the development of indinavir immunoassays.
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Ghoshal Mitali
Patwardhan Aniruddha P.
Sigler Gerald
Amick Marilyn L.
Ceperley Mary E.
Roche Diagnostics Operations Inc.
Roche Diagnostics Operations Inc.
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