Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-05-09
1999-12-14
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
252700, 25230116, 25230121, 25230133, 549215, 549219, 549220, 549221, 435 4, 435 71, 435968, 436543, 436544, 436547, 436548, C09K 300
Patent
active
060015616
ABSTRACT:
Chemiluminescent electron-rich aryl-substituted 1,2-dioxetane compounds are disclosed in which the aryl group is poly-substituted with suitable electron-donating groups such that the light-emitting pattern of the molecule results in a very high luminescent count, thus providing for a sensitive and precise assay for haptens, analytes, polynucleotides and the like. These substituted aryl-containing 1,2-dioxetane compounds can be used as direct labels in an immunoassay or when derivatized with an appropriate leaving group, can be used as a substrate for a enzyme immunoassay. The unusual chemiluminescence of the compounds allows the timing of the luminescent reaction to be exactly controlled.
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Hu Roger C.
Wang Nai-Yi
Abbott Laboratories
Anderson Regina M.
Chin Christopher L.
Nguyen Bao-Thuy L.
Porembski Priscilla E.
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