Indenyl imidazoles

Details Indenyl imidazoles Indenyl imidazoles

1989-11-06

1991-06-25

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23356

Patent

active

050268686

ABSTRACT:
The invention provides 4(5)-substituted imidazole derivatives of formula ##STR1## and their acid addition salts, in which either X is --CH.sub.2 -- and R.sub.1 is --CN, --COOH, COO(lower alkyl), --CHO, --CO(lower alkyl), lower alkyl of 3 or 4 carbon atoms, lower alkenyl, or lower (hydroxy alkyl) or X is ##STR2## --C(:CH--R)-- or --CH(CH.sub.2 R)--, where R is hydrogen or lower alkyl, and R.sub.1 is lower alkyl, and R.sub.3 and R.sub.4 are each hydrogen, methyl, ethyl, methoxy, or halogen, and novel intermediates and processes for their preparation. These compounds, in particular when R.sub.1 is lower alkyl, lower alkenyl, or lower (hydroxy alkyl), possess valuable pharmacological properties and are useful especially as selective .alpha..sub.2 -receptor antagonists.

REFERENCES:
patent: 4464358 (1984-08-01), Cox
patent: 4689339 (1987-08-01), Karjalainen et al.
Chemical Abstracts, 105:218736c (1986), Scheinin, H., et al.
Eur. J. Pharmacol., 1986, 129 (1-2), 113-21.
Chemical Abstracts, vol. 72, No. 5, Feb. 2, 1970.

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