Indene inhibitors of COX-2

Details Indene inhibitors of COX-2 Indene inhibitors of COX-2

1997-10-28

1999-02-09

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549318, A61K 3134, C07D30733

Patent

active

058695249

ABSTRACT:
This invention provides compounds of formula 1 having the structure ##STR1## wherein: R.sup.1 is hydrogen, halogen, alkyl, alkoxy, fluoroalkoxy, trifluoromethyl, alkylthio, or SCF.sub.3

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Shen, T. Y. et al., Indene derivatives useful as PAF-antagonists, Chemical Abstracts, 104:5652q, (1986) pp. 513-514.
Shen, T. Y. et al., Antiinflammatory aliphatic 1-alkylidene-3-indenyl amines, Chemical Abstracts, 75:63491e, (1971) p. 428.
Brewster, K. et al., Structure of the Indene-3-acetic Acids, J Chem Soc, (1972) pp. 941-943.
Shen, T. Y. et al., Synthetic Chemistry of Sulindac and Indene Derivatives, Adv in Drug Res, Simmonds, A. B. ed., 12:4.2, (1977) pp. 149-164, 204.
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