Indene derivatives as pharmaceutical agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S659000

Reexamination Certificate

active

08084503

ABSTRACT:
Compounds of formula (Ia):wherein R1, R2, R3, R4a, R4b, R5and R6are defined herein, as well as other indene derivatives are disclosed herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

REFERENCES:
patent: 3682983 (1972-08-01), Prezewowsky et al.
patent: 3869467 (1975-03-01), Guthrie et al.
patent: 3962275 (1976-06-01), Guthrie et al.
patent: 5686621 (1997-11-01), Clark et al.
patent: 6046185 (2000-04-01), Burgoyne et al.
patent: 2001/0010293 (2001-08-01), Ishida et al.
patent: 1 084 718 (1960-07-01), None
patent: 1-290624 (1989-11-01), None
patent: 5-221901 (1993-08-01), None
patent: 5-221901 (1993-08-01), None
patent: 5-221924 (1993-08-01), None
patent: WO 93/13124 (1993-07-01), None
patent: WO 94/14833 (1994-07-01), None
patent: WO 96/11939 (1996-04-01), None
patent: WO 2004/092100 (2004-10-01), None
JP 5-221901 A, English translation, Aug. 1993.
Hara, “Azasteroid. IV. Synthesis of B-Azacholane Derivative,”Yakugaku Zasshi 78: 1030-1033, Sep. 1958.
Lettré and Wener, “Mehrwertige Alkohole aus Sterinen and Sterinderivaten. IV. 7.8-seco-Derivate des Cholestanols,”Justus Liebigs Annalen Der Chemie 697: 217-221, 1966.
Ahmad and Khan, “The Baeyer-Villiger Oxidation of 5α-Cholestane-3,6-Dione,”Acta Chim. Acad. Sci. Hung. 106(2): 111-113, 1981.
Buckingham et al., “6-Phenylazocholestane derivatives: Reassignment of the Structures of Products from Phenylhydrazine and Ozonised Cholesterol Derivatives,”J. Chem. Soc.(C)18: 1703-1706, 1967.
Clinton et al., “Steroidal[3,2-c]pyrazoles. II. Androstanes, 19-Norandrostanes and their Unsaturated Analogs,”Journal of the American Chemical Society 83: 1478-1491, Mar. 20, 1961.
Cookson et al., “Photochemical Rearrangement of α-Hydroxy-ketones to Lactones,”J. Chem. Soc. (C): 2494-2500, 1968.
Dauben and Brookhart, “Stereocontrolled Synthesis of Steroidal Side Chains,”J. Am. Chem. Soc. 103: 237-238, 1981.
Gumuimg id="CUSTOM-CHARACTER-00001" he="3.13mm" wi="2.12mm" file="US08084503-20111227-P00001.TIF" alt="custom character" img-content="character" img-format="tif" ?ka et al, “Oxidative Cleavage of the Double Bond of 7-Dehydrocholesterol Acetate Peroxide,”Polish Journal of Chemistry 57(4/5/6): 403-411, 1983.
Hara, “Azasteroid. IV. Synthesis of B-Azacholane Derivative,” Chemical Abstracts Online, Accession No. 1959:17427, 1959. See alsoYakugaku Zasshi 78(9): 1030-1033, Sep. 1958.
Kaspar and Witzel, “Steroid Binding to the Cytosolic Estrogen Receptor From Rat Uterus. Influence of the Orientation of Substituents in the 17-Position of the 8β- and 8α-Series,”J. steroid Biochem. 23(3): 259-265, 1985.
Lettréand Werner, “Polyols from steroids and steroid derivatives. IV. 7,8-Seco-derivatives of cholestanols,” Chemical Abstracts Online, Accession No. 1967:46521, 1967. See AlsoJustus Liebigs Annalen Der Chemie 697: 217-221, 1966.
Madaio et al., “Minor 5,6-Secosterols From The Marine SpongeHippospongia communis. Isolation and Synthesis of (7Z,22E,24R)-24-Methy1-5,6-Secocholesta-7,22-Diene-3β,5β,6-Triol,”Journal of Natural Products 53(3): 565-572, May-Jun. 1990.
Manson et al., “Steroidal Heterocycles. VII. Androstano[2,3-d]isoxazoles and Related Compounds,”J. Med. Chem. 6(1): 1-9, Jan. 18, 1963.
Mincione and Bovicelli, SynthesisviaOrganoiron Complexes of 9-(4-Keto-1-Methylcyclohex-2-eny1)-8-Keto-des-AB-Ergost-22,23-ene; A Useful Chiral Intermediate in Steroid Synthesis,Heterocycles 23(7): 1607-1610, 1985.
Reichstein and Meystre, “Über Bestandteile der Nebennierenrinde und verwandte Stoffe—Allo-pregnan-diol-(3, 17)-Derivate der 17(β)-Reihe. Weiterer Beweis für die Zugehörigkeit der Substanzen P und K zur 17(β)-Reihe,”Helv. Chim. Acta 22(III): 728-741, 1939.
Rodewald and Piotrowski, “Secosteroids. I. Synthesis of vic-Diols in B-Secocholestane Group,”Journal Prakt. Chem. 330(5): 775-881, 1988.
Rodewald and Wielogórski, “Selective Esterification of Hydroxyl Groups in Methyl Ester of 3β,8α-Dihydroxy-7,8-Secocholestan-7-oic Acid,”Roczniki Chemii Ann. Soc. Chim. Polonorum 51(4): 809-814, 1977.
Speckamp et al., “6-Thiasteroids A Novel Stereoselective Preparation of 6-Heterosteroids,”Tetrahedron Letters 38: 3405-3408, 1974.
Suginome and Yamada, “Photoinduced Transformations. 77. A Four-Step Substitution of a Carbonyl Group of Steroidal Ketones by an Oxygen Atom. A New Method for the Synthesis of Cyclic Ethers,”Journal of Organic Chemistry 50(14): 2489-2494, 1985.
Westmijze et al., “Ag(I)-Assisted Hydrolysis of Mestranol Methanesulfonate Into Epimestranol,”Tetrahedron Letters 21: 2665-2666, Apr. 15, 1980.
Chemical Abstracts Database, Accession No. 120:77523, Aug. 1993.
Chemical Abstracts Database, Accession No. 112:211000, Nov. 1989.
Chemical Abstracts Database, Accession No. 101:192278, 1983.
Chemical Abstracts Database, Accession No. 82:73301, 1974.
Beilstein Database, Beilstein Registry No. 3061562, 1968.
Beilstein Database, Beilstein Registry No. 3102039, 1967.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Indene derivatives as pharmaceutical agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indene derivatives as pharmaceutical agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indene derivatives as pharmaceutical agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4308544

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.