Indene derivatives and process for the preparation thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S277000, C514S510000, C544S174000, C546S339000, C560S056000

Reexamination Certificate

active

07745439

ABSTRACT:
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.

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Berger et al.: The Mechanisms of Action of PPARs. Annu Rev Med, vol. 53, p. 409-435, 2002.
C.F. Koelsch, Electrophilic Properties of Ethyl 3-Phenylindone-2-carboxylate, XP-002470836, pp. 2088-2091, (1960).
Andrea Cappelli, et al., Synthesis and Characterization of a New Benzofulvene Polymer . . . , JOC Notes, XP-002462155, pp. 9473-9476, (2003).
Kuo-Jui Chang, et al., Cobalt-catalyzed regioselective carbocyclization reaction of o-iodophenyl ketones . . . , XP-002470837, p. 1, (2004).
Dinesh Kumar Rayabarapu et al., Nickel-catalyzed regioselective carbo- cyclization of ortho-halophenyl ketones . . . , XP-002470838, p. 1, (2002).
M.R. Barvian et al., 1-oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast . . . , XP-002470839, p. 1, (1997).
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