Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-04-12
2010-06-29
Kwon, Brian-Yong S (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S277000, C514S510000, C544S174000, C546S339000, C560S056000
Reexamination Certificate
active
07745439
ABSTRACT:
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
REFERENCES:
patent: 3642785 (1972-02-01), Shen et al.
patent: 6448260 (2002-09-01), Cousins et al.
patent: WO 93/08799 (1993-05-01), None
Barvian et al.: 1-Oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast growth factor receptor-1 tyrosine kinase. Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 22, p. 2903-2908, 1997.
Rayabarapu et al.: Regioselective Synthesis of Indenols via Nickel-Catalyzed Carbocyclization Reaction. J Org Chem, vol. 68, p. 6726-6731, 2003.
Berger et al.: The Mechanisms of Action of PPARs. Annu Rev Med, vol. 53, p. 409-435, 2002.
C.F. Koelsch, Electrophilic Properties of Ethyl 3-Phenylindone-2-carboxylate, XP-002470836, pp. 2088-2091, (1960).
Andrea Cappelli, et al., Synthesis and Characterization of a New Benzofulvene Polymer . . . , JOC Notes, XP-002462155, pp. 9473-9476, (2003).
Kuo-Jui Chang, et al., Cobalt-catalyzed regioselective carbocyclization reaction of o-iodophenyl ketones . . . , XP-002470837, p. 1, (2004).
Dinesh Kumar Rayabarapu et al., Nickel-catalyzed regioselective carbo- cyclization of ortho-halophenyl ketones . . . , XP-002470838, p. 1, (2002).
M.R. Barvian et al., 1-oxo-3-aryl-1H-indene-2-carboxylic acid derivatives as selective inhibitors of fibroblast . . . , XP-002470839, p. 1, (1997).
Jose Vicente et al., Palladium-assisted formation of carbon-carbon bonds, XP-002470840, p. 1, (1996).
Ahn Jin Hee
Cheon Hyae Gyeong
Jung Won Hoon
Kang Hye Jung
Kang Seung Kyu
Baek Bong-Sook
CJ Corp.
Jeil Pharm. Co., Ltd.
Korea Research Institute of Bioscience and Biotechnology
Korea Research Institute of Chemical Technology
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