Indazolecarboxamides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546199, A61K 31445

Patent

active

058176764

ABSTRACT:
Indazolecarboxamides are used as antagonists and partial agonists for the serotonin receptor 5-HT.sub.4 and provide therapeutic methods for treatment of disorders caused by or affected by dysfunction of the 5-HT.sub.4 receptor.

REFERENCES:
patent: 3145215 (1964-08-01), Kirchner
patent: 5552398 (1996-09-01), King
Bockaert et al. "The 5HT4 receptor: a place in the sun" Tips v. 131 pp. 141-145, 1992.
Feletou et al. "Serotoninergic receptor subtype in coronary artery smooth muscle from youn and atherosclerotic rabbit" Index Medicus 94:133110, 1994.
Robert W. Hamilton, J. Heterocyclic Chem., 13, 545-553 (1976).
Kaumann, et al., Bio. Med. Chem. Let., 2, 419-420 (1992).
Derwent Abstract, Belgium 770068 (1970).
Derwent Abstract, Japanese 8081-858 (1972).

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