Indazole compounds useful as protein kinase inhibitors

Details Indazole compounds useful as protein kinase inhibitors Indazole compounds useful as protein kinase inhibitors

2006-05-09

2006-05-09

Wilson, James O. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S364100, C548S300100, C548S358100

Reexamination Certificate

active

07041687

ABSTRACT:
The present invention provides compounds of formula I:or a pharmaceutically acceptable derivative thereof, wherein R1, R2, V1, V2, and V3are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of AKT, PKA, PDK1, p70S6K, or ROCK kinase, mammalian protein kinases involved in proliferative and neurodegenerative disorders. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of utilizing those compositions in the treatment of various disorders.

REFERENCES:
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Nicolaides, E.D., et al., “Potential antiviral agents,” J. Med. Chem., 11(1):74-79 (1968).

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