Indane sulfonamide anti-arrhythmic agents and use

Details Indane sulfonamide anti-arrhythmic agents and use Indane sulfonamide anti-arrhythmic agents and use

1990-04-17

1991-04-09

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564 82, 564354, 564374, 564384, A61K 3118, C07C31108

Patent

active

050065610

ABSTRACT:
Novel 5-alkanesulphonamido-2-[N-(4-alkanesulphonamidophenoxyalkyl)-N-methylamino ]indane and 5-alkanesulphonamido-2-[N-(4-alkanesulphonamidophenyl-alkyl)-N-methylamino ]indane compounds have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. The most preferred member compouned is 5-methanesulphonamido-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino] indane. Methods for preparing these compounds from known starting materials are provided.

REFERENCES:
patent: 4959500 (1990-09-01), Schleifstein

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