Indane derivatives and salts thereof

Details Indane derivatives and salts thereof Indane derivatives and salts thereof

1987-04-16

1988-12-20

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

546206, 564 91, 564 92, 564 99, 564158, 564184, 564211, 564222, 564300, 564307, 564374, 564378, 564387, 564389, C07C 87457

Patent

active

047926287

ABSTRACT:
Indane derivatives and their salts represented by the general formula (1), ##STR1## wherein R.sup.1 is an amino group which may have lower alkyl groups as the substituents, a hydroxylimino group, an alkanoylamino group having 1 to 10 carbon atoms which may have halogen atoms as the substituents, a lower alkylsulfonylamino group, a phenylsulfonylamino group which may have lower alkyl groups as the substituents on the phenyl ring, a benzoylamino group having lower alkyl groups as the substituents on the phenyl ring, and a phenyl-lower alkylamino group having a hydroxyl groups or a lower alkyl groups as the substituents on the phenyl ring, R.sup.2 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, an amino group, an amino-lower alkyl group, a lower alkanoylamino group, a lower alkanoylamino-lower alkyl group which may have halogen atoms as the substituents, a lower alkylthio group, a 1-piperidinesulfonyl group, or a lower alkenyl group; R.sup.3 is a hydrogen atom, a lower alkyl group, or a halogen atom; R.sup.4 and R.sup.5 are the same or different from each other, and are each a hydrogen atom, or a lower alkyl group; provided that when R.sup.1 is a hydroxylimino group, then R.sup.2 and R.sup.3 should not be hydrogen atoms at the same time.
The indane derivatives and their salts are useful as preventive and curative agents for various diseases and disorders caused by the excessive formation and accumulation of the active oxygen radicals and the peroxidized substances in the living body, and/or the defects of phylaxis mechanisms of the living body, for example anti-arreriosclerotic agents, carcinogenesis preventive agents, carcinostatic agents, anti-inflammatory agents, analgesics, autoimmune disease curative agents, platelets aggregation inhibitory agents, hypotensive agents, anti-hyperlipemic agents, retinosis of immature infant and cataract preventive and curative agents.
The indane derivatives and their salts are also useful as antioxidants for oils and fats being contained in processed foods.

REFERENCES:
patent: 2916490 (1959-12-01), Schenck et al.
patent: 3637740 (1972-01-01), Sarges
patent: 3709996 (1973-01-01), Gittos et al.
Deana et al "2-(Aminomethyl)phenols, A New Class of Saluretic Agents", J. of Med. Chem., 1983, vol. 26, No. 4, pp. 580-585.

Affiliated with

Also associated with

Rating

Indane derivatives and salts thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indane derivatives and salts thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indane derivatives and salts thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1910243