Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-12-12
1997-02-18
Datlow, Philip I.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540519, 540521, 540522, C07D47104, C07D49804, C07D51304, A61K 3155
Patent
active
056042213
ABSTRACT:
The present invention relates to certain novel indane-2-mercaptoacetylamide disulfide derivatives of the formula ##STR1## useful as inhibitors of enkephalinase.
REFERENCES:
patent: 3334091 (1967-07-01), Houlihan
patent: 3334095 (1967-08-01), Houluhan
patent: 4080449 (1978-03-01), Croisier et al.
patent: 4320057 (1982-03-01), Freed et al.
patent: 4391752 (1983-07-01), Crossley
patent: 4399136 (1983-08-01), Hassall et al.
patent: 4415496 (1983-11-01), Harris et al.
patent: 4487929 (1984-12-01), Hassall et al.
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4584294 (1986-04-01), Ruyle
patent: 4658024 (1987-04-01), Attwood et al.
patent: 4692438 (1987-09-01), Hassall et al.
patent: 4716232 (1987-12-01), Ternansky
patent: 4734504 (1988-03-01), Holmes
patent: 4734505 (1988-03-01), Holmes
patent: 4762924 (1988-08-01), Hassall et al.
patent: 4772701 (1988-09-01), Attwood et al.
patent: 4782149 (1988-11-01), Lawton et al.
patent: 4785093 (1988-11-01), Hassall et al.
patent: 4808713 (1989-02-01), Attwood et al.
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4826980 (1989-05-01), Hassall et al.
patent: 4879309 (1989-11-01), Doll et al.
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5208230 (1993-05-01), Flynn et al.
patent: 5238932 (1993-08-01), Flynn et al.
patent: 5252601 (1993-10-01), Flynn et al.
patent: 5308841 (1994-05-01), Flynn et al.
patent: 5362727 (1994-11-01), Robl
patent: 5366973 (1994-11-01), Flynn et al.
patent: 5389628 (1995-02-01), Flynn et al.
patent: 5420271 (1995-05-01), Warshawsky et al.
patent: 5424425 (1995-06-01), Flynn et al.
patent: 5428158 (1995-06-01), Warshawsky et al.
patent: 5430145 (1995-07-01), Flynn et al.
patent: 5455242 (1995-10-01), Warshawsky et al.
patent: 5457196 (1995-10-01), Warshawsky et al.
Warshawsky et al, Chem. Abstract 119:180824d (1993), for EP-534,363.
34th Nat'l Organic Symposium, Williamsburg, VA, Jun. 11-15, 1995 (poster #133), Robl.
ACS Meeting -Aneheim, CA Apr. 2-7, 1995 (poster #161), Oinuma.
ACS Meeting in Chicago, IL Aug. 24, 1995 (poster No. 64), Simpkins.
Powell Jerry S. et al., Journal of American College of Cardiology, vol. 17, No. 6, pp. 137B-142B (May 1991).
Davis, Harry R. et. al., Supplement I Circulation, vol. 86, No. 4 p. I-220 (0873), (Oct. 1992).
Burkholder, et al. Bioorganic and Medical Chem. Letters, vol. 3, No. 2, pp. 231-234, 1993.
Flynn et al., J. Med. Chem. 1993, 36 2420-2423.
Fournie-Zaluski, Marie-Claude et al., J. Med. Chem., 1992 vol. 35, pp. 1259-1266.
W. H. Parsons et al. Biochemical and Biophysical Research Communications vol. 117, No. 1, 1993 (Nov. 30, 1983).
Flynn, et al., J. Am. Chem. Soc. 109, 7914 (1987).
Flynn, et al., Peptide Chemistry (1987); T. Shiba & Sakakibara (ed.), Protein Research Foundation, Osaka (1988), pp. 631-636.
Flynn, et al., Tetrahedron Letters, vol. 31 (6), 815-88 (1990).
Attwood, et al., J. Chem. Soc. Perkin Trans. I, pp. 1011-1019 (1986).
Natoff, et al., Drugs of the Future, vol. 12 (5): 475-483 (1987).
J. Med. Chem. 1992, 35, 823-832, Timothy D. Ocain et al.
Flynn et al., Bioorganic and Medical Chem. Letters, vol. 1, 309, 1991.
Fournie-Zaluski, Marie-Claude et al., J. Med. Chem., 1992 vol. 35, pp. 2473-2481.
French, John F, Jour. of Pharm and Exper. Therapeutics, vol. 268, No. 1, pp. 180-186 (1994).
Beight Douglas W.
Flynn Gary A.
Kehne John H.
Mehdi Shujaath
Warshawsky Alan M.
Datlow Philip I.
Merrell Pharmaceuticals Inc.
Stemerick David M.
LandOfFree
Indane-2-mercaptoacetylamide disulfide derivatives useful as inh does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indane-2-mercaptoacetylamide disulfide derivatives useful as inh, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indane-2-mercaptoacetylamide disulfide derivatives useful as inh will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1602614