Indan derivatives and pharmaceutical preparation thereof

Details Indan derivatives and pharmaceutical preparation thereof Indan derivatives and pharmaceutical preparation thereof

1988-11-15

1991-07-09

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514381, 514438, 514562, 514602, 514603, 548252, 548254, 549065, 560010, 562428, 564086, 564089, A61K 31215, C07C32330, C07C31120

Patent

active

050306529

ABSTRACT:
Indan derivatives of the formula: ##STR1## wherein R.sup.1 is substituted or unsubstituted phenyl, naphthyl or sulfur-containing heterocyclic group, and R.sup.2 is hydroxy-methyl or a group of the formula: ##STR2## wherein R.sup.3 is hydrogen atom or lower alkyl and R.sup.4 is cycloalkyl, lower alkoxycarbonyl-phenyl, carboxy-phenyl, nitrogen-containing heterocyclic group, lower alkyl, or lower alkyl having a substituent selected from lower alkoxycarbonyl, carboxy, lower alkoxycarbonyl-phenyl, carboxy-phenyl, lower alkoxycarbonyl-cycloalkyl and carboxy-cycloalkyl, or a pharmaceutically acceptable salt thereof, which are useful as a platelet aggregation-inhibiting agent and as an agent for the treatment, amelioration and/or prophylaxis of a variety of thrombosis or embolism, coronary and cerebral vascular smooth muscle vellication, asthma, and the like, processes for the preparation thereof, and pharmaceutical composition containing said compound as an active ingredient.

REFERENCES:
patent: 3383414 (1968-05-01), Houlihan

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