Indacrinone having enhanced uricosuric

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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562462, 514423, 514569, 514870, C07C 5980

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active

045103224

ABSTRACT:
The uricosuric and diuretic properties of indacrinone, [6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid, are carefully balanced for maximum therapeutic benefit by manipulation of the proportion of (+) and (-) enantiomers in the final product within critical limits.

REFERENCES:
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patent: 4087542 (1978-05-01), Cragoe et al.
patent: 4096267 (1978-06-01), Cragoe et al.
patent: 4374829 (1983-02-01), Harris et al.
Irvin et al., Clin. Pharmacol. Ther., p. 260, (Feb. 1980).
deSolms et al., J. Med. Chem., 21, (No. 5), 437-443, (1978).
Woltersdorf et al., ACS Symposium Series No. 83, Diuretic Agents, pp. 219-220, (1978).
Tobert et al., Clin. Pharmacol. Ther., p. 343, (Mar. 1981).
Woltersdorf Jr., Otto-Journal of Labelled Compounds and Radio pharmaceuticals, Vol. XVII, No. 5, 6/12/1979, pp. 635-639.
Chem. Abst., vol. 93, No. 15.

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