Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-02-03
1985-04-09
Killos, Paul J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
562462, 514423, 514569, 514870, C07C 5980
Patent
active
045103224
ABSTRACT:
The uricosuric and diuretic properties of indacrinone, [6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid, are carefully balanced for maximum therapeutic benefit by manipulation of the proportion of (+) and (-) enantiomers in the final product within critical limits.
REFERENCES:
patent: 3313813 (1967-04-01), Cragoe et al.
patent: 4087542 (1978-05-01), Cragoe et al.
patent: 4096267 (1978-06-01), Cragoe et al.
patent: 4374829 (1983-02-01), Harris et al.
Irvin et al., Clin. Pharmacol. Ther., p. 260, (Feb. 1980).
deSolms et al., J. Med. Chem., 21, (No. 5), 437-443, (1978).
Woltersdorf et al., ACS Symposium Series No. 83, Diuretic Agents, pp. 219-220, (1978).
Tobert et al., Clin. Pharmacol. Ther., p. 343, (Mar. 1981).
Woltersdorf Jr., Otto-Journal of Labelled Compounds and Radio pharmaceuticals, Vol. XVII, No. 5, 6/12/1979, pp. 635-639.
Chem. Abst., vol. 93, No. 15.
Blaine Edward H.
Cragoe, Jr. Edward J.
Hirschmann Ralph F.
Nancarrow, deceased John F.
Nancarrow, executrix by Elisabeth M.
Killos Paul J.
Merck & Co. , Inc.
Robertson Alice O.
Speer Raymond M.
Sudol Michael C.
LandOfFree
Indacrinone having enhanced uricosuric does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Indacrinone having enhanced uricosuric, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indacrinone having enhanced uricosuric will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1170734