Indacene compounds and methods for using the same

Details Indacene compounds and methods for using the same Indacene compounds and methods for using the same

1990-04-23

1993-02-23

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

H61K 3164

Patent

active

051890291

ABSTRACT:
A new group of fluorescent organic materials having a variety of uses are described. They are especially useful as dye compounds in dye laser systems, and as photochemical agents in the treatment of sensitive diseased tissues using photodynamic therapy techniques. The materials involve a tri-cyclic compound such as 4,4'-difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene, the disodium salt of 4,4- difluoro-1,3,5,7,8-pentamethyl-4-bora-3a,4a-diaza-s-indacene-2,6-disulfoni c acid monohydrate, and 4,4-difluoro-1,3,5,7-tetramethyl-8-ethyl-4-bora-3a,4a-diaza-s-indacene, having the following structures: ##STR1##

REFERENCES:
patent: 4774339 (1988-09-01), Haugland et al.
patent: 4799230 (1989-01-01), Boyer
Wories, H. J. "A Novel Water Soluble Fluorescent Probe: Synthesis, Luminescence, and Biological Properties of the Sodium Salt of the 3,3', 5,5'-tetramethyl-2,2'-pyrromethene-1,1'-BF.sup.2 Complex" Recueil Des. Travaux Chemiques des Pays-Bas, 104/11, Nov. 1985, pp. 288-291.
Pavlopoulos, Theodore G.; Shah, Mayur and Boyer, Joseph H., "Laser Action From a Tetramethylpyrromethene-BF.sup.2 Complex" Applied Optics, vol. 27, No. 24, pp. 4998-4999.

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