Incrementally truncated nucleic acids and methods of making...

Details Incrementally truncated nucleic acids and methods of making... Incrementally truncated nucleic acids and methods of making...

2008-02-19

2010-10-26

Steele, Amber D. (Department: 1639)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S006120, C435S410000, C435S091500, C536S023100, C506S023000, C506S026000

Reexamination Certificate

active

07820413

ABSTRACT:
A series of methods that utilize the incremental truncation of nucleic acids are described to create a plurality of modified nucleic acids and hybrid polypeptides. A plurality of substantially all possible single base-pair deletions of a given nucleic acid sequence is created. A method of making shuffled incremental truncated nucleic acids, which is independent of nucleic acid sequence homology, is also described. These methods can be used in protein engineering, protein folding, protein evolution, and the chemical synthesis of novel hybrid proteins and polypeptides.

REFERENCES:
patent: 7332308 (2008-02-01), Benkovic et al.
Ostermeier et al (Combinatorial protein engineering by incremental truncation, PNAS, vol. 96, pp. 3562-3567, Mar. 1999).

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