Incremental macromolecule construction methods

Details Incremental macromolecule construction methods Incremental macromolecule construction methods

1987-09-02

1990-07-03

Lall, Parshotam S.

Boots, shoes, and leggings

436 86, 436 89, 935 87, G06F 314

Patent

active

049396668

ABSTRACT:
A preferred embodiment of the invention is a method for constructing a polypeptide chain having a substantially predetermined conformation. Preferably a known stable well-mapped polypeptide structure is used as a starting point, and additional peptide units are incrementally added on while maintaining favorable enthalpic and entropic contributions to stability. Preferably a library of oligopeptide blocks is used to provide candidates for the additional peptide units. Preferably the library includes numerous precomputed parameters for each of the blocks, e.g. parameters for estimating energetic effects of varying the conformation parameters.

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Small Business Innovation Phase II Grant Application of Creative BioMolecules, Inc., Dec. 1985.
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