Increasing the HDL level and the HDL/LDL ratio in human serum wi

Food or edible material: processes – compositions – and products – Treatment of live animal

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426601, A23D 900

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055783341

ABSTRACT:
A method of increasing the HDL concentration and the HDL/LDL concentration ratio in human serum by providing a balance between a sufficient and required proportion of cholesterol-free saturated fatty acids in the daily dietary fat of the human and a sufficient and required, but not excessive, proportion of polyunsaturated fatty acids comprising linoleic acid in dietary fat, while the remaining proportion of fatty acids and energy from the dietary fat is provided by monounsaturated fatty acids comprising oleic acid. The saturated fatty acids must constitute between 20% and 40% by weight of the daily dietary fat based upon dietary fat accounting for 30% of the total dietary energy consumption, and linoleic acid must constitute between 15% and 40% by weight of dietary fat. In this way, the required proportional intake of polyunsaturated fatty acids enhances the formation of HDL from VLDL and/or decreases the clearance of HDL, while an excessive proportional intake of polyunsaturated fatty acids and monounsaturated fatty acids is avoided to assure a sufficient dietary availability of saturated fatty acids which are required for sufficient VLDL synthesis and HDL production.

REFERENCES:
patent: 3649295 (1972-03-01), Bernhart
patent: 5223285 (1993-06-01), DeMichele
patent: 5380544 (1995-01-01), Kleman
patent: 5382442 (1995-01-01), Perlman
patent: 5514407 (1996-05-01), Perlman
Swern 1979 Baileys Industrial Oil and Fat Products vol. 1, 4th edition John Wiley & Sons New York pp. 311-332 and 363-638.
Argiculture Handbook No. 8-4, U.S.D.A. Science and Education Administration, Composition of Foods: Fats and Oils.
Berry et al., "Physicochemical characteristics of palm olein and soybean oil blends," Palm Oil Technol. Eighties, Rep. Proc. Int. Conf. pp. 483-498 (1981) (pub. 1983).
Charnock et al., "Dietary modulation of lipid metabolism and mechanical performance of the heart," 3rd Int. Symp. on Lipid Metabolism in the Normal and Ischemic Heart (Sep. 9-10, 1991).
Choi et al., "Effect of dietary n-3 polyunsaturated fatty acids on cholesterol synthesis and degradation in rats of different ages," Lipids 24(1):45-50 (1989).
Demacker et al., "Increased Removal of remnants of triglyceride-rich lipoproteins on a diet rich in polyunsaturated fatty acids," European J. of Clin. Invest. 21:197-203 (1991).
Grundy and Denke, "Dietary Influences on serum lipids and lipoproteins," J. Lipid Research 31:1149-1172 (1990).
Grundy, "Comparison of Monounsaturated Fatty Acids and Carbohydrates for Lowering Plasma Cholesterol," N. Eng. J. Med. 314:745-748 (1986).
Grundy et al., "Influence of stearic acid on cholesterol metabolism relative to other long-chain fatty acids.sup.1-3," American J. Clin. Nutr. 60(suppl.):986S-990S (1994).
Fujikawa, "Manufacture of Salad Oil," Jpn. Kokai Tokkyo Koho JP 61,293,389 [86,293,389] (Dec. 24, 1986).
Haga, "Manufacture of edible Oils," Jpn. Kokai Tokkyo Koho JP 61,296,096 [86,296,096] (Dec. 26, 1986).
Han et al., "Effect of palm oil blending on the thermal and oxidative stability of soybean oil," Han'guk Sikp'um Kwahakhoechi 23(4):465-70 (1991).
Hayes et al., "Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates.sup.1-4," Am. J. Clin. Nutr. 53:491-498 (1991).
Hayes and Kholsa, "Dietary fatty acid thresholds and cholesterolemia," FASEB 6:2600-2607 (1992).
Hegsted et al., "Quantitative Effects on Dietary Fat on Serum Cholesterol in Man," Amer. J. of Clin. Nutr. 17:281-295 (1965).
Hegsted et al., "Dietary fat and serum lipids: an evaluation of the experimental data.sup.1-4, " Amm. J. of Clin. Nutr. 57:875-883 (1993).
Heyden, "Polyunsaturated and Monounsaturated Fatty Acids in the Diet Prevent Coronary Heart Disease via Cholesterol Reduction," Ann. Nutr. Metab. 38:117-122 (1994).
Jacobs, et al., "Variability in Individual Serum Cholesterol Response to Change in Diet," Arteriosclerosis, 3:349-356 (1983).
Kajimoto et al., "Influence of blend ratio of vegetable oils on their thermal oxidation and decomposition of tocopherol," Nippon Eiyo, Shokuryo Gakkaishi 44(6):499-505 (1991).
Katan et al., "Effects of fats and fatty acids on blood lipids in humans: an overview1-4," Am. J. Clin. Nutr. 60(suppl):1017S-1022S (1994).
Khosla and Hayes, "Dietary fat saturation in rhesuss monkeys affects LDL concentrations by modulating the independent production of LDL apolipoprotein B," Biochem. Biophys. Acta 1083:46-56 (1991).
Khosla and Hayes, "Comparison between the effects of dietary saturated (16:0), monounsaturated (18:1), and polyunsaturated (18:2) fatty acids on plasma lipoprotein metabolism in cebus and rhesus monkeys fed cholesterol-free diets," Am. J. Clin. Nutr. 55:51-62 (1992).
Kifli et al., "Physical properties of interesterified palm oil/palm oil fractions with other vegetable oils," Palm Oil. Prod. Technol. Eighties, Rep. Proc. Int. Conf. pp. 303-314 (1981) (published 1983).
Kim, "Relationship between the triacylglycerol composition and foaming of mixed coconut oil under deep-fat frying," Agric. Biol. Chem. 52(3):693-699 (1988).
Lim et al., "Oxidative stability of Malaysian palm oil and its blends," Yukagaku 39(12):1045-1049 (1990).
Litherland et al., "Preparation of chocolate fats by wet fractionation of soya oil," Abst. of EP 428,200 May 22, 1991, GB 89/25,943 (Nov. 16, 1989).
Majumdar et al., "Vanaspati and margarine fat base from palm oil and palm stearin by corandomization with cottonseed oil," J. Oil Technol. Assoc. India 18(2):37-38 (1986).
Mensink and Katan, "Effect of Dietary Fatty Acids on Serum Lipids and Lipoproteins," Arteriosclerosis and Thrombosis 12:911-919 (1992).
Murakami et al., "Effect of processed oils and fats on cholesterol metabolism. IV. Effect of palm stearin and changes in its effect by blending with soybean oil and further randomizing," Yukagaku 41(3):196-202 (1992).
Murakami et al., "Effect of processed oils and fats on cholesterol metabolism. V. Effect of lard, its blend with palm olein and their randomized oil," Yukagaku 41(7):530-537 (1992).
Pronczuk et al., "Dietary myristic, palmitic, and linoleic acids modulate cholesterolemia in gerbils," FASEB J. 8:1191-1200 (1994).
Siguel and Maclure, "Relative Activity of Unsaturated Fatty Acid Metabolic Pathways in Humans," Metabolism 36:664-669 (1987).
Sundram et al., "Dietary palmitic acid results in lower serum cholesterol than does a lauricmyristic acid combination in normolipemic humans," Am. J. Clin. Nutr. 59:841-846 (1994).
Sundram et al., "Fat (Fatty Acid) Modulation of Metabolism" (2549-2554) FASEB J. 9:A440 (1995) (Abstract).
Suzuki et al., "Fat and oil compositions for frying and spraying," Jpn. Kokai Tokkyo Koho JP 01,262,754 [89,262,754] (Oct. 19, 1989).
Wai, "A critical review of the cholesterolaemic effects of palm oil," Food and Nutrition Bulletin 15:112-123 (1994).
Willet and Sacks, "Chewing the Fat--How Much and What Kind," N. Eng. J. of Med. 324:121-123 (1991).

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