Increasing the absorption rate of insoluble drugs

Details Increasing the absorption rate of insoluble drugs Increasing the absorption rate of insoluble drugs

1978-06-13

1979-04-24

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424181, 424182, 424243, 424254, 424260, 424271, 424285, 424298, 424319, A61K 4700, A61K 3134, A61K 3174, A61K 920

Patent

active

041512731

ABSTRACT:
The absorption in body fluids of poorly soluble drugs is enhanced by forming a glassy solid matrix of a carrier and the drug. A solution of the drug and the carrier is formed at an elevated temperature either with or without a solvent and chilled rapidly to form a solid mass which can be ground to a powder for oral administration in a tablet or capsule.

REFERENCES:
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patent: 2698822 (1955-01-01), Halpern et al.
patent: 3297804 (1967-01-01), Iwamoto et al.
patent: 3308217 (1967-03-01), Lowy et al.
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patent: 3330727 (1967-07-01), Lees
patent: 3374146 (1968-03-01), Blicharz et al.
Sekiguchi et al., Chem. Pharm. Bull. 9:866-872 (1961) Studies on Absorption of Eutectic Mixture.
Sekiguchi et al., Chem. Pharm. Bull. 12:134-144 (1964) Studies on Absorption of Eutectic Mixture.
Goldberg et al., J. Pharm. Sci. 54:1145-1148 (1965) Increasing Dissolution Rates and Gastro-Intestinal Absorption of Drugs via Solid Solutions and Eutectic Mixtures.
Chiou et al., J. Pharm. Sci. 58(12):1505-1509, Dec. 1969, Preparation and Dissolution Characteristics of Several Fast-Release Solid Dispersions of Griseofulvin.

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