Increasing lifespan by modulation of WWP-1 and UBC-18

Details Increasing lifespan by modulation of WWP-1 and UBC-18 Increasing lifespan by modulation of WWP-1 and UBC-18

2008-08-15

2011-11-15

Kaushal, Sumesh (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S008000, C800S009000, C435S069100, C435S320100, C435S325000, C435S455000, C536S023100, C536S023200, C536S023400, C530S350000, C530S351000

Reexamination Certificate

active

08058502

ABSTRACT:
Ubiquitin ligase wwp-1 and ubiquitin conjugating enzyme ubc-18 are identified in nematodes as mediators of dietary restriction induced longevity and therefore as targets for modulation of lifespan in animals. Methods of screening for compounds that modulate longevity by assaying wwp-1 ubiquitination pathway parameters are provided, as are related systems. In addition, methods of using wwp-1 and/or ubc-18 to modulate longevity or delay onset of age-related diseases are described.

REFERENCES:
Chen et al. Oncogene 26:2386-2394; 2007.
Carrano et al. Nature 460:396-400; 2009.
Lucanic et al. Aging 1:751-752; 2009.
Alcedo and Kenyon (2004) “Regulation ofC. eleganslongevity by specific gustatory and olfactory neurons,”Neuron, 41, 45-55.
Angers et al. (2004) “The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system,”J Biol Chem, 279:11471-11479.
Apfeld and Kenyon (1998) “Cell nonautonomy ofC. Elegans daf-2function in the regulation of diapause and life span,” Cell 95: 199-210.
Apfeld and Kenyon (1999) “Regulation of lifespan by sensory perception inCaenorhabditis elegans,” Nature, 402:804-809.
Arum and Johnson (2007) “Reduced expression of theCaenorhbditis elegansp53 ortholog cep-1 results in increased longevity,”J Gerontol A Biol Sci Med Sci., 62:951-959.
Bauer et al. (2005) “Neuronal expression of p53 dominant-negative proteins in adultDrosophila melanogasterextends life span,”Curr Biol,15:2063-2068.
Bernassola et al. (2008) “The HECT family of E3 ubiquitin ligases: Multiple players in cancer development,”Cancer Cell, 14:10-21.
Bishop and Guarente (2007) “Two neurons mediate diet-restriction-induced longevity inC. elegans,” Nature, 447:545-549.
Blumenthal and Spieth (1996) “Gene structure and organization inCaenorhabditis elegans,” Curr Opin Genet Dev, 6:692-698.
Blumenthal et al. (2002) “A global analysis ofCaenorhabditis elegansoperons,”Nature. 417:851-854.
Carrano et al. 1 (1999) “SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27,”Nat Cell Biol, 193-199.
Chen et al. (2005) “Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells,”J Biol Chem, 280:41553-41561.
Chen et al. (2007) “The amplified WWP1 gene is a potential molecular target in breast cancer,”Int J Cancer, 121(1):80-87.
Chen et al. (2007) “Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer,”Oncogene, 26(16):2386-2394.
Conkright et al. (2001) “Lung Kruppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase,”J Biol Chem276:29299-29306.
Dillin et al. (2002) “Rates of behavior and aging specified by mitochondrial function during development,”Science, 298:2398-2401.
Dillin et al. (2002) “Timing requirements for insulin/IGF-1 signaling inC. elegans,” Science, 298:830-834.
Fang et al. (2002) “Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation,”Nat Immunol3, 281-287.
Fay et al. (2003) “lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis inC. elegans,” Development, 130:3319-3330.
Fay et al. (2004) “The coordinate regulation of pharyngeal development inC. elegansby lin-35/Rb, pha-1, and ubc-18,”Dev Biol, 271:11-25.
Feng et al. (2004) “Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways,”J Biol Chem, 279:29681-29690.
Feng et al. (2001) “Mitochondrial electron transport is a key determinant of life span inCaenorhabditis elegans,” Dev Cell, 1:633-644.
Fraser et al. (2000) “Functional genomic analysis ofC. eleganschromosome I by systematic RNA interference,”Nature, 408(6810):325-330.
Gallagher et al. (2006) “Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induce conformational change,”PNAS, 103:1717-1722.
Gao et al. (2004) “Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch,”Science. 306:271-275.
Gao et al. (2008) “The SCFFSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 inC. elegans,” Cell Death and Differentiation, 15:1054-1062.
Genbank Accession No. NM—001026307, “Caenorhabditis elegansP-53-like protein family member (cep-1) (cep-1) mRNA, complete cds,” Nov. 13, 2008.
Genbank Accession No. NM—001047651,Caenorhabditis elegansdefective PHArynx development family meember (pha-4) (pha-4) mRNA, complete cds, Nov. 13, 2008.
Genbank Accession No. NM—031483, “Homo sapiensitchy E3 ubiquitin protein ligase homolog (mouse) (ITCH), mRNA,” Mar. 4, 2010.
Genbank Accession No. NM—066140, “Caenorhabditis elegansubiquitin conjugating enzyme family member (ubc-18) (ubc-18) mRNA, complete cds,” Nov. 13, 2008.
Genbank Accession No. AJ000519, “Homo sapiensmRNA for ubiquitin-conjugating enzyme UbcH7,” Oct. 7, 2008.
Genbank Accession No. NM—007013, “Homo sapiensWW domain containing E3 ubiquitin protein ligase 1 (WWP1), mRNA,” Mar. 5, 2010.
Genbank Accession No. NM—025830, “Mus musculus WW domain containing E3 ubiquitin protein ligase 2 (Wwp2), mRNA,” Mar. 12, 2010.
Genbank Accession No. NM—171831, “Caenorhabditis elegansWW domain protein (E3 ubiquitin ligase) family member (wwp-1) (wwp-1) mRNA, complete cds,” Nov. 13, 2008.
Greer et al. (2007) “An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction inC. elegans,” Curr Biol, 17:1646-1656.
Hansen et al. (2005) “New genes tied to endocrine, metabolic, and dietary regulation of lifespan from aCaenorhabditis elegansgenomic RNAi screen,”PLoS Genetics, e17.
Hansen et al. (2008) “A role for autophagy in the extension of lifespan by dietary restriction inC. elegans,” PLoS Genetics, 4(2):e24.
Hoppe et al. (2000) “Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing,”Cell, 102:577-586.
Huang et al. (1999) “Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade,”Science, 286:1321-1326.
Huang et al. (2000) “A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential forCaenorhabditis elegansembryogenesis,”Gene252:137-145.
Ikeda et al. (2000) “The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases,”Virology, 268:178-191.
Ingham et al. (2005) “The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor,”J Biol Chem, 280:34133-34142.
Jones et al. (2006) “Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3,”Science, 312:1223-1227.
Kenyon (2001) “A conserved regulatory system for aging,”Cell, 105:165-168.
Kimura et al. (1997) “daf-2, an insulin receptor-like gene that regulates longevity and diapause inCaenorhabditis elegans,” Science, 277:942-946.
Klass (1977) “Aging in the nematodeCaenorhabditis elegans: major biological and environmental factors influencing life span,”Mech Ageing Dev, 6:413-429.
Laine and Ronai (2007) “Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1,”Oncogene, 26:1477-1483.
Lakowski and Hekimi (1998) “The genetics of caloric restriction inCaenorhabditis elegans,” PNAS, 95:13091-13096.
Lallemand et al. (2005) “AIP4 restricts transforming growth factor-beta signa

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