Increasing gamete production with a gene switch

Details Increasing gamete production with a gene switch Increasing gamete production with a gene switch

2003-12-10

2009-08-25

Bertoglio, Valarie (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S008000, C800S021000

Reexamination Certificate

active

07579515

ABSTRACT:
A method of enhancing the production of gametes in a transgenic non-human animal is carried out by: (a) providing a transgenic non-human animal comprising cells that contain: (i) a response element; (ii) a nucleic acid encoding FSHβ operatively associated with the response element; (iii) an FSHβ promoter; (iv) an FSHβ locus control region operatively associated with the FSHβ promoter; and (v) a nucleic acid encoding a ligand-controllable receptor operatively associated with the FSHβ promoter, wherein the receptor binds to the response element in the presence of the ligand when expressed in a host cell; and (b) administering the ligand to the animal in an amount effective to (i) stimulate the production of FSHβ in the animal above that found in a corresponding untransformed type animal; and (ii) stimulate the production of gametes in the animal to a level greater than that found in the corresponding untransformed animal.

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