Increasing creatine and glycogen concentration in muscle

Details Increasing creatine and glycogen concentration in muscle Increasing creatine and glycogen concentration in muscle

1997-09-29

1999-10-19

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 514 23, 514 53, 514 54, 514565, A61K 3828, A61K 3170, A61K 31715, A61K 31195

Patent

active

059689005

DESCRIPTION:

BRIEF SUMMARY
The present invention concerns the retention of creatine within the body, and relates in particular but not exclusively to a method and composition for increasing creatine uptake in humans. The invention also concerns a method and composition for simultaneously increasing glycogen concentration in muscle.
Creatine (methylglycocyamine, H.sub.2 NC=NH.multidot.N(CH.sub.3)CH.sub.2 CO.sub.2 H) is known to be present in the muscles of vertebrates. It is present in a phosphorylated and a non-phosphorylated form and has been shown to be involved in muscular contraction and the development of fatigue. Creatine is produced naturally by the body, but is also obtained from animal foods.
Most bodily creatine is present in muscle, and it is believed that increasing the amount of creatine within muscle favorably affects muscular performance and the amount of work which can be done by the muscle. Accordingly, it is held desirable to be able to influence creatine retention in the body.
Glycogen, (C.sub.6 H.sub.10 O)x, is a carbohydrate found in animal cells and is convertible from and to glucose. Athletes endeavour to increase muscle glycogen content before competing in order to enhance muscle performance.
In this specification the term "active derivative" means anything derived from or a precursor of the relevant substance that acts in the same or similar way in the body to the substance, or which is processed into the substance when placed into the body. The terms serum and plasma can be interchanged.
According to the invention there is provided a method of increasing creatine retention in the human or animal body by causing an increase in blood plasma creatine concentration and causing a substantially simultaneous increase in blood plasma insulin concentration.
The plasma creatine concentration may be increased by ingestion and/or in fusion of creatine or an active derivative thereof.
The plasma insulin concentration may be increased by infusion of insulin or an active derivative thereof and/or by the ingestion of an agent operable to cause an increase in the blood plasma insulin concentration.
The agent may be a carbohydrate or an active derivative thereof, preferably a simple carbohydrate. Preferably the carbohydrate is glucose.
Preferably the method comprises the simultaneous ingestion of creatine and an agent operable to cause an increase in the blood plasma insulin concentration substantially simultaneously with the arrival in the plasma of the creatine.
The creatine and/or the agent is preferably orally ingested.
The invention further provides a method of increasing glycogen storage, and particularly glycogen concentration in muscle of the human or animal body by causing an increase in blood plasma carbohydrate concentration and insulin concentration and causing a substantially simultaneous increase in blood plasma creatine concentration.
The plasma creatine concentration may be increased by ingestion and/or infusion of creatine or an active derivative thereof. The plasma carbohydrate, which is desirably glucose and insulin concentrations may be increased by ingestion of carbohydrate or an active derivative thereof, but desirably glucose and/or any other simple carbohydrate and/or by infusion of a carbohydrate or an active derivative thereof, such as glucose or any other simple carbohydrate.
Preferably creatine or an active derivative thereof and glucose and/or another simple carbohydrate are orally ingested.
According to the invention there is further provided a composition for increasing creatine retention in the human or animal body, the composition comprising creatine or an active derivative thereof together with a carbohydrate or an active derivative thereof.
Preferably the composition is in the nature of a dietary supplement.
Preferably the carbohydrate is glucose and/or another simple carbohydrate.
The composition preferably comprises 2 to 8% by weight creatine and 92 to 98% by weight glucose and/or another simple carbohydrate.
According to the invention there is also provided a method of increasing creatin

REFERENCES:
Anon, Pschyrembel -Klinisches Wortberbuch, 1990, Walter de Gruyter, Berlin-New York (1990), pp. 790-792; 902-903.
Haider W. Et al., "Improvement of Cardiac Preservation by Preoperative High Insulin Supply," Database Embase, Elsevier Science Publishers, Amsterdam, NL, J. Thorac, Cardiovasc. Surg. (1984).
Samuel P. Bessman, "The Oringin of theCreatine-Creatine Phosphate Energy Shuttle", pp. 75-81, Heart Creatine Kinase-Chapter 7(1980) .

Affiliated with

Also associated with

Rating

Increasing creatine and glycogen concentration in muscle does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Increasing creatine and glycogen concentration in muscle, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Increasing creatine and glycogen concentration in muscle will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2055419