Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-09-13
1996-04-09
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530314, 530328, A61K 3808, C07K 702
Patent
active
055062067
ABSTRACT:
Polypeptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. These receptor mediated permeabilizers are more efficacious than bradykinin in causing the blood-brain barrier to become more permeable. The permeabilizer A-7 or conformational analogues can be intravenously co-administered to a host together with molecules whose desired destination is the cerebrospinal fluid compartment of the brain. The permeabilizer A-7 or conformational analogues allow these molecules to penetrate the blood-brain barrier and arrive at this destination.
REFERENCES:
patent: 4709010 (1987-11-01), Holzemann et al.
patent: 4923963 (1990-05-01), Stewart et al.
patent: 5112596 (1992-05-01), Malfroy-Camine
patent: 5162497 (1992-11-01), Coy et al.
Kyle et al., "Design and Conformational Analysis of Several Highly Potent Bradykinin Receptor Antagonists," J. Med. Chem., 34(3): 1230-1233 (1991).
Wahl, M., et al., "Effects of Bradykinin on Pial Arteries and Arterioles In Vitro and In Situ," J. Cere. Blood Flow and Metab., 3(2): 231-237 (1983).
Unterberg, A. et al., "The Kallikrein-kinin System As Mediator in Vasogenic Brain Edema, Part I: Cerebral Exposure to Bradykinin and Plasma," J. Neurosurg., 61: 87-96 (1984).
Unterberg, A. et al., "Effects of Bradykinin on Permeability and Diameter of Pial Vessels In Vivo," J. Cere. Blood Flow and Metab., 4(4): 574-585 (1984).
Wahl, M. et al., "Cerebrovascular Effects of Bradykinin," Neural Regulation of Brain Circulation, C. Owman and J. E. Hardebo, eds., Elsevier Science Publ., pp. 419-430 (1986).
Olsen, S.-P. et al., "Substances that Rapidly Augment Ionic Conductance of Endothellum in Cerebral Venules," Acta Physiol. Scand., 127: 233-241 (1986).
Wahl, M. et al., "Effects of Bradykinin on Cerebral Haemodynamics and Blood-Brain Barrier Function," In: Peptidergic Mechanisms in Cerebral Circulation (Edwinssen and McCulloch, Eds.) Chichester, Herwood, pp. 166-190 (1987).
Wahl, M. et al., "Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edeme," J. Cere. Blood Flow and Metab., 8: 621-634 (1988).
Raymond, J. J. et al., "Pharmacological Modification of Bradykinin Induced Breakdown of the Blood-Brain Barrier," Can. J. Neuro. Sci., 13(3): 214-220 (Aug., 1986).
Saria, A. et al., "Vascular Protein Leakage in Various Tissues Induced by Substance P, Capsaicin, Bradykinin, Serotonin, Histamine and by Antigen Challenge," Naunyn-Schniedeberg's Arch. Pharmacol., 324: 212-218 (1983).
Kamitani, T. et al., "Evidence for a Possible Role of the Brain Kallikrein-Kinin System in the Modulation of the Cerebral Circulation," Circulation Research, 57(4): 545-552 (Oct., 1985).
Schurer, L. et al., "Blood-Brain Barrier Permeability and Vascular Reactivity to Bradykinin After Pretreatment with Dexamethasone," Acta Neuropathol., 77: 576-581 (1989).
Marceau, F. et al., "Pharmacology of Kinins: Their Relevance to Tissue Injury and Inflammation," Gen. Pharmacol., 14(2): 209-229 (1983).
Hiesiger et al., "Opening the Blood-Brain and Blood-Tumor Barriers in Experimental Rat Brain Tumors: The Effect of Intracarotid Hyperosmolar Mannitol on Capillary Permeability and Blood Flow," Annals Neurology, 19(1): 50-59 (Jan., 1986).
Barry et al., "Amphotericin B and the Blood-Brain Barrier to Methotrexate," Neurosurgery, 10(2): 224-226 (Feb., 1982).
Williams, B. B., "Pharmacokinetics of Interferon in Blood, Cerebrospinal Fluid, and Brain after Administration of Modified Polyriboinosinic-Polyribocytidylic Acid and Amphotericin B," J. Inf. Disease, 146(6): 819-825 (Dec., 1982).
Ayre, S. G., "New Approaches to the Delivery of Drugs to the Brain," Medical Hypotheses 29: 283-291 (1989).
Unterberg, A. et al., "Blood Flow, Metabolism, and Function of the Brain During Cerebral Administration of Bradykinin," Advances in Neurosurgery, 13: 326-329, Dietz, H. et al. (Eds), Springer-Verlag Berlin Heidelberg (1985).
Rhaleb, N.-E. et al., "Structure-Activity Studies on Bradykinin and Related Peptides: Agonists," Br. J. Pharmacol., 99(3): 445-448 (1990).
Chemical Abstracts, vol. 105 No. 19, 10 Nov. 1986, Columbus, OH, US; abstract No. 164987q.
Rhaleb, N.-E., Chem. Abst. 112(23); 211077z (1990).
Scarso, A. et al., "Synthesis and Biological Activities of Bradykinin Analogues with .psi.(E,CH.dbd.CH) and .psi.(CH.sub.2 --NH) Isosteric Peptide Bond Replacements," Bull. Soc. Chim. Belg. vol. 100, No. 5 pp. 381-399 (1991).
Stewart, "Chemical and Biologic Activity of Peptides Related to Bradykinin" Handbook of Experimental Pharmacology, vol. XXV Supplement, pp. 227-272 (1979).
Yamazaki et al., Peptide Chemistry and Biology, ed. Smith and Rivier, ESCOM, Leiden, pp. 154-156 (1992).
Regoli et al., "Pharmacology of Bradykinin and Related Kinins" Pharmacology Rev. 32(1), pp. 1-46 (1980).
Escher et al., "Biological Activities of Photoaffinity Labeling Analogues of Kinins and their Irreversible Effects on Kinin Receptors" J. Med. Chem. 24, pp. 1409-1413 (1981).
Vavrek et al., Kinins IV (Adv. in Exp. Med. & Biol.), vol. 198A, pp. 543-547 (1986).
Kozarich John W.
Malfroy-Camine Bernard
Musso Gary F.
Alkermes, Inc.
Chan Christina Y.
Prickril Benet
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