Increasing aqueous humor outflow

Details Increasing aqueous humor outflow Increasing aqueous humor outflow

1994-09-23

1999-01-26

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514913, A61K 3119

Patent

active

058639489

ABSTRACT:
A method of increasing aqueous humor outflow in the eye of a human patient to treat glaucoma, the method comprising topically administering to the eye an outflow-increasing amount of an analog of ethacrynic acid having a margin of safety of at least 2.0 and having the formula ##STR1## wherein each X.sub.1 and X.sub.2, independently, is a halogen, H, or CH.sub.3, or X.sub.1 and X.sub.2 together form a substituted or unsubstituted aromatic ring; X.sub.3 is an organic group; and X.sub.4 is OH or an organic group; provided that where X.sub.1 and X.sub.2 are Cl and X.sub.4 is OH, X.sub.3 cannot be 2-methylene-1-oxobutyl; or a pharmaceutically acceptable salt thereof.

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