Increasing aqueous humor outflow

Details Increasing aqueous humor outflow Increasing aqueous humor outflow

1986-12-30

1988-07-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514913, A61K 3119

Patent

active

047570890

ABSTRACT:
A method of increasing aqueous humor outflow in the eye of a human patient including topically administering to the eye an outflow increasing amount of a compound characterized in that it contains one or more groups capable of reacting with sulfhydryl groups in the trabecular meshwork of the eye, and it has a margin of safety of at least 2.0.

REFERENCES:
patent: 3255241 (1966-06-01), Schultz
Chem. Abst. 84:99192h, (1976)-Guenther et al.
Invest. Ophthalmol. Vis. Sci. 22 (6)-752-756, (1982)-Epstein et al.
Magro et al., (1983), Int. Archs. Allergy Appl. Immun. 72, 41.
Epstein et al., (1970), Invest. Ophthalmol. 9 (8), 629.
Lindenmayer et al., (1982), Invest. Ophthalmol. Vis. Sci. 24 (6), 710.
Epstein et al., (1981), Invest. Ophthalmol. Vis. Sci. 20 (5), 625.
Anderson et al., (1980), Invest. Ophthalmol. Vis. Sci. 91 (1), 13.
Kahn et al., (1983), Invest. Ophthalmol. Vis. Sci. 24 (3), 1283.
Scott et al., (1984), Invest. Ophthalmol. Vis. Sci. 25 (5), 599.
Freddo et al., (1984), Invest. Ophthal. Mol. Sci. 25 (3), 278.

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