Increasing antibody affinity by altering glycosylation in the im

Details Increasing antibody affinity by altering glycosylation in the im Increasing antibody affinity by altering glycosylation in the im

1995-01-13

1998-02-03

Feisee, Lila

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 7021, 435 711, 43524027, 4351721, 4241331, 5303873, 935 49, 935 50, A61K 39395, C12P 2108, C12P 2104, C12N 1513

Patent

active

057143501

ABSTRACT:
The present invention provides methods for producing mutationally-altered immunoglobulins and compositions containing such mutationally-altered immunoglobulins, wherein the mutationally-altered immunoglobulins have at least one mutation that alters the pattern of glycosylation in a variable region and thereby modifies the affinity of the immunoglobulin for a preselected antigen. The methods and compositions of the invention provide immunoglobulins that possess increased affinity for antigen. Such glycosylation-altered immunoglobulins are suitable for diagnostic and therapeutic applications.

REFERENCES:
Zoller et al. Methods in Immunology 1983 vol. 100 p. 469.
Wright et al. Embo 10(10) p. 2717, 1991.
Waldmann Science vol. 252, p. 1657, 1991.
Co et al. Journal of Immunology 143(8) 1989.
Hird et al Genes & Cancer Chapter 17 183-198, 1990 "Immunotherapy with monocolonal antibodies".
Wallick et al. J. Exp. Medicine 168:1099, 1988.

Affiliated with

Also associated with

Rating

Increasing antibody affinity by altering glycosylation in the im does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Increasing antibody affinity by altering glycosylation in the im, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Increasing antibody affinity by altering glycosylation in the im will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-661395