Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1991-08-01
1992-12-29
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C12P 2102
Patent
active
051750945
ABSTRACT:
The invention relates to increased expression of HBcAg. Methods are disclosed which exhibit increased levels of expression of HBcAg. Increased levels of expression is also achieved by various modifications of the HBcAg sequence.
REFERENCES:
patent: 4710463 (1987-12-01), Murray
Yie et al. "High level expression of HBcAg in E. coli by modification of the 5'end of the HBc gene" Chinese Journal of Virology 4(4):312-318 (1988).
Kim et al. "Expression and Secretion of Hepatitis B Viral Mutant Cure Antigen" Korean Journal of Microbiology 27(3):169-175 (1989).
Grosjean et al. "Preferential codon usage in prokaryotic genes: the optimal condon-anticodon interaction energy and the selective codon usage in efficiently expressed genes" Gene 18:199-209 (1982).
R. A. Bhat et al., Hepatology 11:271 (1989).
R. E. Lanford et al., Viral Immunology 1:97 (1987).
Becton Dickinson and Company
Johnson Michelle
Schwartz Richard A.
Stierwalt Brian K.
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