Increased expression of .alpha.-1-antitrypsin in expression vect

Details Increased expression of .alpha.-1-antitrypsin in expression vect Increased expression of .alpha.-1-antitrypsin in expression vect

1993-05-06

1995-08-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Vector, per se

536 235, 536 241, 435 692, 4351723, C12N 1511, C12N 1512, C12N 1563, C12P 2100

Patent

active

054398240

ABSTRACT:
The present invention relates to novel expression vectors and a method to increase the expression of .alpha..sub.1 -antitrypsin (AAT) from expression vectors encoding for the same through the inclusion of the Intron II sequence. Preferably, the Intron II sequence is included in its naturally occurring position, immediately after Exon II. Also, the invention is methods of therapy using the method and the expression vectors.

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