Increased bacterial CoA and acetyl-CoA pools

Details Increased bacterial CoA and acetyl-CoA pools Increased bacterial CoA and acetyl-CoA pools

2011-03-08

2011-03-08

Raghu, Ganapathirama (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S252800, C435S471000, C435S190000, C435S193000, C435S194000, C435S069100, C435S091100, C435S320100

Reexamination Certificate

active

07901924

ABSTRACT:
Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor molecules.

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