Incorporation of biological molecules into bioactive glasses

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424422, 424484, 424601, 424602, 424724, 501 11, 501 12, 501 32, 501 53, 501 55, 501 63, 501 72, 514953, A61F 1300, A61K 4702

Patent

active

058741097

ABSTRACT:
Carriers comprising silica-based glass providing for the controlled release of biologically active molecules, their methods of preparation, and methods of use are disclosed. The carriers are prepared using a sol-gel-derived process. Biologically active molecules are incorporated within the matrix of the glass during production.

REFERENCES:
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4613516 (1986-09-01), Kucheria et al.
patent: 4772203 (1988-09-01), Scheunemann
patent: 4849378 (1989-07-01), Hench et al.
patent: 4851046 (1989-07-01), Low et al.
patent: 4851150 (1989-07-01), Hench et al.
patent: 4859525 (1989-08-01), Hench et al.
patent: 4869906 (1989-09-01), Dingeldein et al.
patent: 4976736 (1990-12-01), White et al.
patent: 5074916 (1991-12-01), Hench et al.
patent: 5108436 (1992-04-01), Chu et al.
patent: 5200334 (1993-04-01), Dunn et al.
patent: 5207710 (1993-05-01), Chu et al.
patent: 5270300 (1993-12-01), Hunziker
patent: 5344654 (1994-09-01), Rueger et al.
patent: 5356635 (1994-10-01), Raman et al.
patent: 5371018 (1994-12-01), Avnir et al.
patent: 5374427 (1994-12-01), Stille et al.
patent: 5420081 (1995-05-01), Mattes et al.
patent: 5464450 (1995-11-01), Buscemi et al.
patent: 5591453 (1997-01-01), Ducheyne et al.
patent: 5637507 (1997-06-01), Wicks et al.
patent: 5643789 (1997-07-01), Ducheyne et al.
patent: 5693513 (1997-12-01), Pope
patent: 5702717 (1997-12-01), Cha et al.
patent: 5711958 (1998-01-01), Cohn et al.
patent: 5739020 (1998-04-01), Pope
American Academy of Orthopaedic Surgeons, 1993, Bone Formation and Bone Regeneration. Tampa, FL: ).
Andersson et al., "Calcium Phosphate Formation at the Surface of Bioactive Glass in vitro", J. Biomed Mater. Res. 25:1019-1030 (1991).
Andersson et al., "On the Bioactivity of Silicate Glass", J. Non-Cryst Solids 129:145-151 (1991).
Avnir et al., "Encapsulation of Organic Molecules and Enzymes in Sol-Gel Glasses", American Chemical Society, Ch. 27, pp. 385-404 (1992).
Beck et al., J. Bone Miner. Res. 6(9):961 (1991).
Boone et al., "Bone Attachment to Hydroxyapatite Coated Polymers", J. Biomed Mater. Res. 23(A2):183-199 (1989).
Braun et al., "Biocatalysis by Sol-Gel Entrapped Enzymes", J. of Non-Crystalline Solids, 147 and 148:739-743 (1992).
Braun et al., "Biochemically Active Sol-Gel Glasses -- The Trapping of Enzymes", Materials Letters 10:1-5 (1990).
Canalis et al., "Systemic and Local Factors and the Maintenance of Bone Quality", Calcified Tissue Int. 53:S90-S93 (1993).
Canalis et al., "Insulin Like Growth Factors Decrease Collagen Degradation and Collagenase Expression in Bone Cultures", J. Bone Miner. Res. 8:S237 (1993).
Chesmel et al., "TGF-.beta. Enhances Osseointegration In Vivo", Bioceramics, 6:21-25 (1993).
Cornell and Lane, "Newest Factors in Fracture Healing", Clin. Orthop. 277:297-311 (1992).
Cornell et al., "Treatment of Experimental Osteomyelitis with Antibiotic-Impregnated Bone Graft Substitute", J. of Orthopaedic Research, 11(5):619-626 (1993).
Damen and Ten Cate, "The Effect of Silicic Acid on Calcium Phosphate Precipitation", J. Dental Res. 68(9):1355-1359 (1989).
Damien and Parsons, "Bone Graft and Bone Substitutes: A Review of Current Technology and Applications", J. Applied Biomater. 2:187-208 (1991).
Downes et al., "Growth-Hormone Loaded Bioactive Ceramics", J. Mater. Sci.:Mater.Med., 2:176-180 (1991).
Ducheyne P., "Bioceramics: Material Characteristics Versus In Vivo Behavior", J. Biomed. Mater. Res. 21(A2):219-236 (1987).
Ducheyne and Cuckler, "Bioactive Ceramic Prosthetic Coatings", Clin. Orthop. Rel. Res. 76:102-114 (1992).
Ellerby et al., "Encapsulation of Proteins in Transparent Porous Silicate Glasses Prepared by the Sol-Gel Method", Science 255:1113-1115 (1992).
Friedman et al., "In Vivo Mechanical and Histological Evaluation of Bone in Growth and Apposition in the Rabbit Female".
Gerhart et al., "Healing Segmental Femoral Defects in Sheep Using Recombinant Human Bone Morphogenetic Protein", Clin. Orthop. 293:317-326 (1993).
Gombotz et al., "Stimulation of Bone Healing by Transforming Growth Factor-Beta Released from Polymeric", J. App. Biomat., 5:141-150 (1994).
Gunasekaran et al., "Mineralized Collagen As A Substitute for Autograft Bone that can Deliver Bone Morphogenic Protein", 19th Annual Meeting of the Society for Biomaterials, p. 258 (1993).
Hench, L.L., "Bioceramics and the Origin of Life" J. Biomed Mater. Res. 23:685-703 (1989).
Hench, L.L., "Bioactive Ceramics", Ann. N. Y. Acad. Sci. 523:54-71 (1988).
Hench, L.L., "Bioceramics: from Concept to Clinic", J. Am. Ceram. Soc. 74(7):1487-1510 (1991).
Hock et al., "Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication", Endocrinology 122(1):254-260 (1988).
Johnson et al., "Resistant Nonunions and Partial or Complete Segmental Defects of Long Bones", Clin. Orthop. 277:229-237 (1992).
Johnson et al., "Bone Morphogenetic Protein Augmentation Grafting of Resistant Femoral Nonunions", Clin. Orthop. 230:257-265 (1988).
Johnson et al., "Repair of Segmental Defects of the Tibia with Cancellous Bone Grafts Augmented with Human Bone Morphogenetic", Clin. Orthop. 236:249-257 (1988).
Johnson et al., "Distal Metaphyseal Tibial Nonunion. Deformity and Bone Loss Treated by Open Reduction, Internal Fixation, and Human Bone Morphogenetic Protein (hBMP)", Clin. Orthop. (1990).
Joyce et al., "Transforming Growth Factor-.beta. in the Regulation of Fracture Repair", Orthop Clin. North. Am. 21(1):199-209 (1990).
Joyce et al., "Transforming Growth Factor-.beta. and the Initiation of Chondrogenesis and Osteogenesis in the Rat Femur", J. Cell Biol. 110(6):2195-2207 (1990).
Kokubo, T., "Bioactive Glass Ceramics: Properties and Applications", Biomaterials 12(2):155-163 (1991).
Li et al., "Effects of Ions in Aqueous Media on Hydroxyapatite Induction by Silica Gels and its Relevance to Bioactivity of Bioactive Glasses and Glass-Ceramics", J. Appl. Biomater., 4:221-229 (1993).
Li et al., "Apatite Formation Induced by Silica in a Stimulated Body Fluid", J. Amer. Ceram. Soc., 75:2094-2097 (1993).
Li et al., "An Investigation of Bioactive Glass Powders by Sol-Gel", J. Applied Biomater 2:231-239 (1991).
Liu et al., "Development and Characterization of a New-Type Bioactive Glass-Ceramic", Annual Meeting of the Society For Biomaterials, p. 5 (1993).
Lucas et al., "Ectopic Induction of Cartilage and Bone By Water-Soluble Proteins From Bovine Bone Using a Collagenous Delivery Vehicle", J. Biomed Mater. Res.
Mccarthy et al., "Regulatory Effects of Insulin-Like Growth Factors I and II on Bone Collagen Synthesis in Rat Calvarial Cultures", Endocrinology 124(1):301-309.
Meikle et al., "Effect of Poly DL-Lactide-Co-Glycolide Implants and Xenogeneic Bone Matrix-Derived Growth Factors On Calvarial Bone Repair in the Rabit", Biomaterials 15(7):513-521 (1994).
Miclau et al., "In Vitro Pharmacokinetics of Antibiotic Release from Locally Implantable Materials", J. of Orthopaedic Research, 11:627-632 (1993).
Olmedo et al., "Intramedullary TGF-.beta. Administration and Osteogenesis in an In Vivo Rat Model", 19th Annual Meeting of the Society for Biomaterials, p. 6 (1993).
Otsuka et al., "A Novel Skeletal Drug Delivery System for Antibiotic Drugs Using Self-Setting Bioactive Bone Cement Based on CaO-SiO.sub.2 -P.sub.2 O.sub.5 Glass", In: Yamamuro T, Kokubo T, Nakamura, T, eds. Bioceramics 5 5th ed. Kyoto, 241-248 (1992).
Pereira et al., "Calcium Phosphate Formation on Sol-Gel-Derived Bioactive Glasses In Vitro", J. of Biomed. Mat. Res., 28:693-698 (1994).
Radin et al., "The Effect of Calcium Phosphate Ceramic Composition and Structure on In Vitro Behavior. II. Precipitation", J. Biomed Mater. Res. 27:35-45 (1993).
Rawlings, R.D., "Composition Dependence of the Bioactivity of Glassed", J. Mater. Sci. Letters 11:1340-1343 (1992).
Sampath et al., BMP-7 J. Biol. Chem. 267(28):20352 (1992).
Schepers et al., "Bioactive Glass Particulate Material as a Filler for Bone Lesions", J. Oral Rehabil. 18:439-452 (1991).
Silbermann, M., "In Vitro Systems for Inducers of Cartilage and Bone Development", Biomaterials, 11:47-49 (1990).
Stoscheck et al., "I

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Incorporation of biological molecules into bioactive glasses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Incorporation of biological molecules into bioactive glasses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Incorporation of biological molecules into bioactive glasses will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-304393

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.