Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2002-09-18
2008-12-02
Wilson, James O. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S300100, C548S301700, C548S302700, C548S303400
Reexamination Certificate
active
07459471
ABSTRACT:
The present invention provides an inclusion compound having a cucurbituril derivative of the formula 1 as a host molecule and a metal complex of the formula 2 as a guest molecule. A pharmaceutical composition having an anticancer effect can be obtained by using the inclusion compound according to the present invention. The pharmaceutical composition can prevent effective components from being biologically degraded in vivo and can exhibit continuous drug effect for a long time just by a single dosage by controlling the release time of the platinum complex once it reaches target tumor cells.
REFERENCES:
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M.B. de Oliveira et al., “New perfluorophthalate complexes of platinum(II) with chemotherapeutic potential”, Metal-Based Drugs, 1996 3(3), pp. 117-122, Freund, 1996.
Ui-Rak Kim et al., “The study about interation of cis-diaminedichloroplatin (cis-DDP) complexes with DNA base, 1-methylcytosine, for development of anti-tumor drug”, Taehan Hwahakhoe Chi, 1990 34(4), pp. 331-339, 1999.
Beverly A. Teicher et al., “Combination of etanidazole with cyclophosphamide and platinum complexes”, Cancer dhemotherapy and Pharmacology, 1991 28(3), pp. 153-158, 1991.
Jeon Young Jin
Kim Kimoon
Kim Soo Young
Ko Young Ho
Postech Foundation
Rothwell Figg Ernst & Manbeck
Ward Paul V.
Wilson James O.
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